UniProt Accession

 TPM2_MOUSE; P58774; P02560; P46901 

Genbank Protein ID

 X12650; M81086; X58381 

Genbank Nucleotide ID

 CAA31181.1; AAA40484.1; CAA41271.1 

Protein Name

 Tropomyosin beta chain 

Protein Synonyms/Alias

 Beta-tropomyosin; Tropomyosin-2 

Gene Name

 Tpm2 

Gene Synonyms/Alias

 Tpm-2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
30	EQAEADKKQAEDRCK	ubiquitination	[1]
37	KQAEDRCKQLEEEQQ	ubiquitination	[1]
48	EEQQALQKKLKGTED	ubiquitination	[1]
51	QALQKKLKGTEDEVE	ubiquitination	[1]
59	GTEDEVEKYSESVKD	ubiquitination	[1]
65	EKYSESVKDAQEKLE	ubiquitination	[1]
70	SVKDAQEKLEQAEKK	ubiquitination	[1]
128	DESERGMKVIENRAM	ubiquitination	[1]
149	ELQEMQLKEAKHIAE	ubiquitination	[1]
168	KYEEVARKLVILEGE	ubiquitination	[1]
198	GDLEEELKIVTNNLK	acetylation	[2]
205	KIVTNNLKSLEAQAD	ubiquitination	[1]
213	SLEAQADKYSTKEDK	acetylation	[2]
213	SLEAQADKYSTKEDK	ubiquitination	[1]
220	KYSTKEDKYEEEIKL	ubiquitination	[1]
226	DKYEEEIKLLEEKLK	ubiquitination	[1]
231	EIKLLEEKLKEAETR	ubiquitination	[1]
233	KLLEEKLKEAETRAE	ubiquitination	[1]
251	RSVAKLEKTIDDLED	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 61 61 Phosphoserine; by PIK3CG.
 MOD_RES 252 252 Phosphothreonine.
 MOD_RES 283 283 Phosphoserine.  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005862; C:muscle thin filament tropomyosin; TAS:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0006936; P:muscle contraction; TAS:MGI.
 GO:0043462; P:regulation of ATPase activity; IEA:Compara. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.