CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Ddx60 
Protein Synonyms/Alias
  
Gene Name
 Ddx60 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
622NVDSGMKKLEEFLKSubiquitination[1]
962TSRGSYYKDQAQARQubiquitination[1]
1221EKNLEIPKDCTYANQubiquitination[1]
1229DCTYANQKAIDDQLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1711 AA 
Protein Sequence
MEKKYTGFLK IMSHLILETM SKADYSSLFN DFVESEFFLI DGDSLLITCA CERSLKPGQS 60
LHFFYLVERY LLDVISKGGQ FAIVFFKDAE YAYFNVPELL TLRTALILHL QKNTTVEVWT 120
KFSNCLSEEW NICLGQSCPY FLILADEGLN DLQTHLFNFV VIQAWAAKVN IVLFSGQTSD 180
ILRLYAYFMQ SSHGMQMFFK ENKRMIMIVY KSLIQQLEKY RDMALAHLFG DLKFNDMEEK 240
VCETVSLLKQ LWPEGSDIRC VFCVTSCSLF LEMYHCYLES REKGASEEMS KVKQKTDNCL 300
TLKDMEDFCK LHCLSVALLL HVPLSQRARS RFITANWIQD LKTVLKMKKW CEYFILSNLD 360
MFESWSLNLL HLSDLSDEPL LRNIAFYYEN ENKEGLDLNV GDAIMNEYVH LWDTVSKLVR 420
KFDVGKPIPL RTTKVHFLEK TPSPIKESSQ EMMPNLGFIP MSCNLVDEFT GDILKDLPFL 480
MSDDPIVTSL VKHKEFDELV HWHSHRPLSD DYDRTKCIGD ANRRDPNHLK RLQKYHSFQR 540
FYGESLESVT SKTITTQGPK PKKDCIKSKS TKAHETKAEI IKRENKKRLI AEEEQKEEQK 600
WNALSFSIEE EMRKNVDSGM KKLEEFLKSC KSRSVKAQVE RVGLQACLKA WKEHCQAEGE 660
TTKDLSIAVN MMKRIHSLLD KHSELLQEAD QKLIARCLKY LGFCELAVSL YPTQDASDGI 720
KMKKKNKYSV GIGPARFQLQ YMGHYLIREE RKDPDPRVQD FIPDTWQREL LDVVDNYESA 780
VIVAPTSSGK TYASYYCMEK VLKESDEGVV VYVAPTKALV NQVAATVEYR YAKNMPAGES 840
LCGVFTRDYR HDALNCQVLI TVPACFEILL LAPHRQNWVK RIRYVIFDEV HCLGGEIGAE 900
IWEHLLVMIR CPFLALSATI SNPQHLTEWL QSVKRYWKQV DSTMEERTVS KRTGTSRGSY 960
YKDQAQARQS YKVRLVLYGE RYNDLEKYLC SVRQGDVCFD HFHPCAALTI DHIEKYGFPS 1020
DLALSPRESI QLYDTMCQVW KSWPQAQSLC PENFTQFKNK IVIKKLDARK YEESLKEEFT 1080
NWVKNGNEEE ARMVLKKLSP DYHEHSGRML DFFPCLVEKL RKMEKLPALF FLFKLNIVEE 1140
CAENAFEFLE KKQEEKRPPK ADKEARTTAN KLRKVKKSLE KQKTVDEKGQ KSSRRLDESV 1200
MHETEHNYLL QTLEKNLEIP KDCTYANQKA IDDQLLQRVF HRVRFERKGE TLKRLAERGI 1260
GYHHSSMSAK EKQLVEILFR KGFIRVVTAT GTLALGINMP CKSVVFAQNS VYLDALNYRQ 1320
MSGRAGRRGQ DLLGDVYFFD IPLPKIGKLI KSKVPELRGQ FPLSISLILR LMLLASKADD 1380
LEDGKAKALS VLKHSLLSFK QPRAIDMLKL YFLYSLQFLV KEGHIDQEGN PTGFAGLVSH 1440
LHYHEPSNLV FVSFLVKGLF HKLCQPTREG PKRFSEDVME KLVLVLANLF GRRYIPAKFY 1500
EVNSKFYQSK VFLDDLPEDF SHALLEYNTQ VTEDFASFLL MVSRLADMKQ EYQLSLSKIE 1560
FTGKECEDSP LVSHLMNCKE GRVAVSPFVC LSGNFDVDLL SPGVPNHVIL HTLGINHTQA 1620
PVLWPYALDS QGRKIPLNAY ALDFYKHGSL IGLVQDNRIH PGEAYSLLKD FNLIIKSISV 1680
SLRELCENEE DNVVLAFEQL STSFQEKFEL V 1711 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
 GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB.
 GO:0003727; F:single-stranded RNA binding; ISS:UniProtKB.
 GO:0051607; P:defense response to virus; IDA:MGI.
 GO:1900245; P:positive regulation of MDA-5 signaling pathway; ISS:UniProtKB.
 GO:1900246; P:positive regulation of RIG-I signaling pathway; ISS:UniProtKB. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS