UniProt Accession

 PHOP_ECOLI; P23836 

Genbank Protein ID

 D90393; M81433; U00096; AP009048; M74924; X59307 

Genbank Nucleotide ID

 BAA14390.1; AAA24377.1; AAC74214.1; BAA35952.1; AAA92732.1; CAA41997.1 

Protein Name

 Transcriptional regulatory protein PhoP 

Protein Synonyms/Alias

  

Gene Name

 phoP 

Gene Synonyms/Alias

 b1130; JW1116 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
17	ALLRHHLKVQIQDAG	acetylation	[1]
87	ARESWQDKVEVLSAG	acetylation	[1]
101	GADDYVTKPFHIEEV	acetylation	[1]
171	NNGKVVSKDSLMLQL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system PhoQ/PhoP involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. 

Sequence Annotation

 DOMAIN 1 116 Response regulatory.
 MOD_RES 51 51 4-aspartylphosphate (By similarity).  

Keyword

 3D-structure; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS