UniProt Accession

 RGS7_MOUSE; O54829; E9QLB9 

Genbank Protein ID

 AF011360; AC102499; AC113050; AC117693; AC117734; AC159973 

Genbank Nucleotide ID

 AAC99483.1 

Protein Name

 Regulator of G-protein signaling 7 

Protein Synonyms/Alias

 RGS7 

Gene Name

 Rgs7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
228	RNPHKTRKSVYGLQN	ubiquitination	[1]
349	VGREQFLKFLESEFS	ubiquitination	[1]
402	SAINLDSKSYDKTTQ	ubiquitination	[1]
412	DKTTQNVKEPGRYTF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations and in synaptic vesicle exocytosis (By similarity). 

Sequence Annotation

 DOMAIN 37 112 DEP.
 DOMAIN 255 316 G protein gamma.
 DOMAIN 333 448 RGS.
 MOD_RES 229 229 Phosphoserine.
 MOD_RES 434 434 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Lipoprotein; Palmitate; Phosphoprotein; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0044292; C:dendrite terminus; IDA:MGI.
 GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:MGI.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000591; DEP_dom.
 IPR015898; G-protein_gamma-like_dom.
 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00610; DEP
 PF00631; G-gamma
 PF00615; RGS 

SMART

 SM00049; DEP
 SM00224; GGL
 SM00315; RGS 

PROSITE

 PS50186; DEP
 PS50058; G_PROTEIN_GAMMA
 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.