CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029086
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Septin-8 
Protein Synonyms/Alias
  
Gene Name
 SEPT8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171SLDLVTMKKLDSKVNubiquitination[1, 2]
172LDLVTMKKLDSKVNIubiquitination[2, 3]
176TMKKLDSKVNIIPIIubiquitination[1, 2, 3]
191AKADTISKSELHKFKubiquitination[2, 3]
302YELYRRCKLEEMGFQubiquitination[2, 4]
327LQETYEAKRKEFLSEubiquitination[5]
329ETYEAKRKEFLSELQubiquitination[2]
351QMFVNKVKETELELKubiquitination[2]
358KETELELKEKERELHubiquitination[2]
367KERELHEKFEHLKRVubiquitination[2]
400TNAFNRRKAAVEALQubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 60
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDERPIVD 120
YIDAQFENYL QEELKIRRSL FDYHDTRIHV CLYFITPTGH SLKSLDLVTM KKLDSKVNII 180
PIIAKADTIS KSELHKFKIK IMGELVSNGV QIYQFPTDDE AVAEINAVMN AHLPFAVVGS 240
TEEVKVGNKL VRARQYPWGV VQVENENHCD FVKLREMLIR VNMEDLREQT HSRHYELYRR 300
CKLEEMGFQD SDGDSQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV KETELELKEK 360
ERELHEKFEH LKRVHQEEKR KVEEKRRELE EETNAFNRRK AAVEALQSQA LHATSQQPLR 420
KDKDKKKASG WSSIYSVTIP 440 
Gene Ontology
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:InterPro. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS