UniProt Accession

 PITX1_RAT; Q99NA7 

Genbank Protein ID

 AB047298; BC061966 

Genbank Nucleotide ID

 BAB41202.1; AAH61966.1 

Protein Name

 Pituitary homeobox 1 

Protein Synonyms/Alias

 Homeobox protein PITX1; Paired-like homeodomain transcription factor 1 

Gene Name

 Pitx1 

Gene Synonyms/Alias

 Ptx1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
5	***MDAFKGGMSLER	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. 

Sequence Annotation

 DNA_BIND 89 148 Homeobox.
 REGION 149 280 Interacts with PIT-1 (By similarity).
 MOTIF 281 294 OAR.
 MOTIF 287 291 Nuclear localization signal (Potential).
 MOD_RES 46 46 Phosphoserine (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).  

Keyword

 Activator; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0000988; F:protein binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:RGD.
 GO:0014707; P:branchiomeric skeletal muscle development; IEA:Compara.
 GO:0051216; P:cartilage development; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0048625; P:myoblast fate commitment; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017970; Homeobox_CS.
 IPR016233; Homeobox_Pitx/unc30.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR003654; OAR_dom. 

Pfam

 PF00046; Homeobox
 PF03826; OAR 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS50803; OAR 

PRINTS