| Tag | Content |
|---|
| CPLM ID | CPLM-000174 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | A-kinase anchor protein 1, mitochondrial |
Protein Synonyms/Alias | Dual specificity A-kinase-anchoring protein 1; D-AKAP-1; Protein kinase A-anchoring protein 1; PRKA1; Spermatid A-kinase anchor protein; S-AKAP |
Gene Name | Akap1 |
Gene Synonyms/Alias | Akap |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 168 | ELSLMGDKAKSIPLG | ubiquitination | [1] | | 621 | GRYVSFLKQTSGAKI | ubiquitination | [1] | | 660 | KALNLIGKKFKELNL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif. |
Sequence Annotation | DOMAIN 561 625 KH.
DOMAIN 712 771 Tudor.
REGION 306 319 PKA-RII subunit binding domain.
MOD_RES 55 55 Phosphoserine.
MOD_RES 101 101 Phosphoserine.
MOD_RES 103 103 Phosphoserine.
MOD_RES 164 164 Phosphoserine (By similarity).
MOD_RES 401 401 Phosphothreonine (By similarity).
MOD_RES 487 487 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; RNA-binding; Transit peptide; Transmembrane. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 857 AA |
Protein Sequence | MGCKTGPKPF GGGETIRPIR IRRCSYFTST DSKMAIQLRS LFPLALPGML ALLGWWWFFS 60
RKKDRLSSSD KQVETLKVGP AIKDRRLSEE ACPGVLSVAP TVTQPPGREE QRCVDKPSTE 120
PLALPRTRQV RRRSESSGNL PSVADTRSQP GPCRDEIAKV ELSLMGDKAK SIPLGCPLLP 180
KDASFPYEAV ERCKQESALG KTPGRGWPSP YAASGEKARE TGGTEGTGDA VLGENVSEEG 240
LLSQECVSEV EKSEFPILAP GGGEGEEVSH GPPQVAELLK KEEYIVGKLP SSFVEPVHSE 300
PVKDEDALEP QVKGSSNTSD RDLAGELDKD ETVPENDQIK QAAFQLISQV ILEATEEFRA 360
TTVGKTVAQV HPTSATQPKG KEESCVPASQ ETSLGQDTSD PASTRTGATA SPSAEALPPK 420
TYVSCLSSPL SGPTKDQKPK NSAHHISLAP CPPPVTPQRQ SLEGASNPRG DDNFVACMAN 480
NSQSVLSVSS LGQCSDPVST SGLEDSCTET ISSSGDKAMT PPLPVSTQPF SNGVLKEELS 540
DLGTEDGWTM DTEADHSGGS DGNSMDSVDS CCGLTKPDSP QSVQAGSNPK KVDLIIWEIE 600
VPKHLVGRLI GKQGRYVSFL KQTSGAKIYI STLPYTQNIQ ICHIEGSQHH VDKALNLIGK 660
KFKELNLTNI YAPPLPSLAL PSLPMTSWLM LPDGITVEVI VVNQVNAGHL FVQQHTHPTF 720
HALRSLDQQM YLCYSQPGIP TLPTPVEITV ICAAPGADGA WWRAQVVASY EETNEVEIRY 780
VDYGGYKRVK VDVLRQIRSD FVTLPFQGAE VLLDSVVPLS DDDHFSPEAD AAMSEMTGNT 840
ALLAQVTSYS ATGLPLIQLW SVVGDEVVLI NRSLVERGLA QWVDSYYASL 890 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |