UniProt Accession

 TPX_ECOLI; P0A862; P37901; P57669; P76047; P77786 

Genbank Protein ID

 U33213; U93212; U00096; AP009048 

Genbank Nucleotide ID

 AAC43517.1; AAC45284.1; AAC74406.1; BAA14906.1 

Protein Name

 Thiol peroxidase 

Protein Synonyms/Alias

 Scavengase P20 

Gene Name

 tpx 

Gene Synonyms/Alias

 yzzJ; b1324; JW1317 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
24	SIPQAGSKAQTFTLV	acetylation	[1]
33	QTFTLVAKDLSDVTL	acetylation	[1, 2, 3]
46	TLGQFAGKRKVLNIF	acetylation	[1, 3]
48	GQFAGKRKVLNIFPS	acetylation	[1]
128	AIADGPLKGLAARAV	acetylation	[1, 3]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [3] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Has antioxidant activity. Could remove peroxides or H(2)O(2) within the catalase- and peroxidase-deficient periplasmic space. 

Sequence Annotation

 DOMAIN 19 168 Thioredoxin.  

Keyword

 3D-structure; Antioxidant; Complete proteome; Direct protein sequencing; Oxidoreductase; Periplasm; Peroxidase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoCyc.
 GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
 GO:0032843; F:hydroperoxide reductase activity; IDA:EcoCyc.
 GO:0008379; F:thioredoxin peroxidase activity; IDA:EcoCyc.
 GO:0045454; P:cell redox homeostasis; IEA:HAMAP.
 GO:0034599; P:cellular response to oxidative stress; IMP:EcoCyc. 

Interpro

 IPR018219; Antioxidant_Tpx_CS.
 IPR002065; Put_TPX.
 IPR013740; Redoxin.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF08534; Redoxin 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2
 PS01265; TPX 

PRINTS