| Tag | Content |
|---|
| CPLM ID | CPLM-004255 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit A2 |
Protein Synonyms/Alias | Calcineurin A2; Calmodulin-binding protein 2 |
Gene Name | CMP2 |
Gene Synonyms/Alias | CNA2; YML057W; YM9958.05 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 22 | AIKIIENKTERPQSS | ubiquitination | [1] | | 36 | STTPIDSKASTVAAA | ubiquitination | [1] | | 109 | DHFKREGKLSAAQAA | ubiquitination | [1] | | 477 | KKLPQAGKSEATPQP | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. |
Sequence Annotation | REGION 501 523 Calmodulin-binding (Potential).
ACT_SITE 205 205 Proton donor (By similarity).
METAL 144 144 Iron (By similarity).
METAL 146 146 Iron (By similarity).
METAL 172 172 Iron (By similarity).
METAL 172 172 Zinc (By similarity).
METAL 204 204 Zinc (By similarity).
METAL 253 253 Zinc (By similarity).
METAL 359 359 Zinc (By similarity).
MOD_RES 31 31 Phosphothreonine.
MOD_RES 489 489 Phosphoserine.
MOD_RES 520 520 Phosphoserine (Potential). |
Keyword | Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 604 AA |
Protein Sequence | MSSDAIRNTE QINAAIKIIE NKTERPQSST TPIDSKASTV AAANSTATET SRDLTQYTLD 60
DGRVVSTNRR IMNKVPAITS HVPTDEELFQ PNGIPRHEFL RDHFKREGKL SAAQAARIVT 120
LATELFSKEP NLISVPAPIT VCGDIHGQYF DLLKLFEVGG DPATTSYLFL GDYVDRGSFS 180
FECLIYLYSL KLNFNDHFWL LRGNHECKHL TSYFTFKNEM LHKYNLDIYE KCCESFNNLP 240
LAALMNGQYL CVHGGISPEL NSLQDINNLN RFREIPSHGL MCDLLWADPI EEYDEVLDKD 300
LTEEDIVNSK TMVPHHGKMA PSRDMFVPNS VRGCSYAFTY RAACHFLQET GLLSIIRAHE 360
AQDAGYRMYK NTKTLGFPSL LTLFSAPNYL DTYNNKAAIL KYENNVMNIR QFNMTPHPYW 420
LPDFMDVFTW SLPFVGEKVT EMLVAILNIC TEDELENDTP VIEELVGTDK KLPQAGKSEA 480
TPQPATSASP KHASILDDEH RRKALRNKIL AVAKVSRMYS VLREETNKVQ FLKDHNSGVL 540
PRGALSNGVK GLDEALSTFE RARKHDLINE KLPPSLDELK NENKKYYEKV WQKVHEHDAK 600
NDSK 604 |
Gene Ontology | GO:0005955; C:calcineurin complex; IDA:SGD. GO:0005737; C:cytoplasm; IDA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IMP:SGD. GO:0006873; P:cellular ion homeostasis; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |