| Tag | Content |
|---|
| CPLM ID | CPLM-019377 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DDB1- and CUL4-associated factor 5 |
Protein Synonyms/Alias | Breakpoint cluster region protein 2; BCRP2; WD repeat-containing protein 22 |
Gene Name | DCAF5 |
Gene Synonyms/Alias | BCRG2; KIAA1824; WDR22 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 583 | RKIYKAYKWLRYSYI | ubiquitination | [1] | | 596 | YISYSNNKDGETSLV | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. |
Sequence Annotation | REPEAT 51 91 WD 1.
REPEAT 99 139 WD 2.
REPEAT 140 180 WD 3.
REPEAT 185 225 WD 4.
REPEAT 277 317 WD 5.
REPEAT 331 370 WD 6.
MOD_RES 626 626 Phosphoserine (By similarity).
MOD_RES 628 628 Phosphoserine (By similarity).
MOD_RES 631 631 Phosphoserine (By similarity).
MOD_RES 632 632 Phosphoserine (By similarity).
MOD_RES 648 648 Phosphoserine.
MOD_RES 651 651 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 942 AA |
Protein Sequence | MEQAIHSRVK PIQLKGEHHS NIFCLAFNSG NTKVFSGGND EQVILHDVES SETLDVFAHE 60
DAVYGLSVSP VNDNIFASSS DDGRVLIWDI RESPHGEPFC LANYPSAFHS VMFNPVEPRL 120
LATANSKEGV GLWDIRKPQS SLLRYGGNLS LQSAMSVRFN SNGTQLLALR RRLPPVLYDI 180
HSRLPVFQFD NQGYFNSCTM KSCCFAGDRD QYILSGSDDF NLYMWRIPAD PEAGGIGRVV 240
NGAFMVLKGH RSIVNQVRFN PHTYMICSSG VEKIIKIWSP YKQPGCTGDL DGRIEDDSRC 300
LYTHEEYISL VLNSGSGLSH DYANQSVQED PRMMAFFDSL VRREIEGWSS DSDSDLSEST 360
ILQLHAGVSE RSGYTDSESS ASLPRSPPPT VDESADNAFH LGPLRVTTTN TVASTPPTPT 420
CEDAASRQQR LSALRRYQDK RLLALSNESD SEENVCEVEL DTDLFPRPRS PSPEDESSSS 480
SSSSSSEDEE ELNERRASTW QRNAMRRRQK TTREDKPSAP IKPTNTYIGE DNYDYPQIKV 540
DDLSSSPTSS PERSTSTLEI QPSRASPTSD IESVERKIYK AYKWLRYSYI SYSNNKDGET 600
SLVTGEADEG RAGTSHKDNP APSSSKEACL NIAMAQRNQD LPPEGCSKDT FKEETPRTPS 660
NGPGHEHSSH AWAEVPEGTS QDTGNSGSVE HPFETKKLNG KALSSRAEEP PSPPVPKASG 720
STLNSGSGNC PRTQSDDSEE RSLETICANH NNGRLHPRPP HPHNNGQNLG ELEVVAYSSP 780
GHSDTDRDNS SLTGTLLHKD CCGSEMACET PNAGTREDPT DTPATDSSRA VHGHSGLKRQ 840
RIELEDTDSE NSSSEKKLKT 860 |
Gene Ontology | GO:0080008; C:Cul4-RING ubiquitin ligase complex; IDA:UniProtKB. GO:0005739; C:mitochondrion; IEA:Compara. GO:0016567; P:protein ubiquitination; IC:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |