CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF16B 
Protein Synonyms/Alias
 Sorting nexin-23 
Gene Name
 KIF16B 
Gene Synonyms/Alias
 C20orf23; KIAA1590; SNX23 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1107SLPVSAEKSHLVPLMubiquitination[1]
1149STSADTMKDNEKLHNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. 
Sequence Annotation
 DOMAIN 1 365 Kinesin-motor.
 DOMAIN 478 529 FHA.
 DOMAIN 1182 1296 PX.
 NP_BIND 102 109 ATP (Potential).  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Lipid-binding; Membrane; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Reference proteome; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1317 AA 
Protein Sequence
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR ERTKTFTYDF 60
SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA YGQTGSGKSY TMMGNSGDSG 120
LIPRICEGLF SRINETTRWD EASFRTEVSY LEIYNERVRD LLRRKSSKTF NLRVREHPKE 180
GPYVEDLSKH LVQNYGDVEE LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM 240
PCETVSKIHL VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANTL 300
AKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR YANRAKNIIN 360
KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT ALSMEEKLQQ NEARVQELTK 420
EWTNKWNETQ NILKEQTLAL RKEGIGVVLD SELPHLIGID DDLLSTGIIL YHLKEGQTYV 480
GRDDASTEQD IVLHGLDLES EHCIFENIGG TVTLIPLSGS QCSVNGVQIV EATHLNQGAV 540
ILLGRTNMFR FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSRENLSAVM LYNPGLEFER 600
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETQ RKETEIVQLQ IRKQEESLKR 660
RSFHIENKLK DLLAEKEKFE EERLREQQEI ELQKKRQEEE TFLRVQEELQ RLKELNNNEK 720
AEKFQIFQEL DQLQKEKDEQ YAKLELEKKR LEEQEKEQVM LVAHLEEQLR EKQEMIQLLR 780
RGEVQWVEEE KRDLEGIRES LLRVKEARAG GDEDGEELEK AQLRFFEFKR RQLVKLVNLE 840
KDLVQQKDIL KKEVQEEQEI LECLKCEHDK ESRLLEKHDE SVTDVTEVPQ DFEKIKPVEY 900
RLQYKERQLQ YLLQNHLPTL LEEKQRAFEI LDRGPLSLDN TLYQVEKEME EKEEQLAQYQ 960
ANANQLQKLQ ATFEFTANIA RQEEKVRKKE KEILESREKQ QREALERALA RLERRHSALQ 1020
RHSTLGMEIE EQRQKLASLN SGSREQSGLQ ASLEAEQEAL EKDQERLEYE IQQLKQKIYE 1080
VDGVQKDHHG TLEGKVASSS LPVSAEKSHL VPLMDARINA YIEEEVQRRL QDLHRVISEG 1140
CSTSADTMKD NEKLHNGTIQ RKLKYELCRD LLCVLMPEPD AAACANHPLL QQDLVQLSLD 1200
WKTEIPDLVL PNGVQVSSKF QTTLVDMIYF LHGNMEVNVP SLAEVQLLLY TTVKVMGDSG 1260
HDQCQSLVLL NTHIALVKED CVFYPRIRSR NIPPPGAQFD VIKCHALSEF RCVVVPEKKN 1320
VSTVELVFLQ KLKPSVGSRN SPPEHLQEAP NVQLFTTPLY LQGSQNVAPE VWKLTFNSQD 1380
EALWLISHLT RL 1392 
Gene Ontology
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IDA:UniProtKB.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.
 GO:0008574; F:plus-end-directed microtubule motor activity; IDA:UniProtKB.
 GO:0045022; P:early endosome to late endosome transport; IMP:UniProtKB.
 GO:0007492; P:endoderm development; ISS:UniProtKB.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; IMP:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0001704; P:formation of primary germ layer; ISS:UniProtKB.
 GO:0006895; P:Golgi to endosome transport; ISS:UniProtKB.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0032801; P:receptor catabolic process; IMP:UniProtKB.
 GO:0001919; P:regulation of receptor recycling; IMP:UniProtKB. 
Interpro
 IPR000253; FHA_dom.
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase.
 IPR001683; Phox.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA
 PF00225; Kinesin
 PF00787; PX 
SMART
 SM00240; FHA
 SM00129; KISc
 SM00312; PX 
PROSITE
 PS50006; FHA_DOMAIN
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2
 PS50195; PX 
PRINTS
 PR00380; KINESINHEAVY.