CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040028
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transducin-like enhancer protein 3 
Protein Synonyms/Alias
  
Gene Name
 TLE3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
176KKRKAEEKDSLSRYDacetylation[1]
253KDLGHNDKSSTPGLKacetylation[1]
447DISQPGSKSPISQLDubiquitination[1, 2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 699 AA 
Protein Sequence
MSYGLNIEMH KQTEIAKRLN TILAQIMPFL SQEHQQQVAQ AVERAKQVTM TELNAIIGVR 60
GLPNLPLTQQ QLQAQHLSHA THGPPVQLPP HPSGLQPPGI PPVTGSSSGL LALGALGSQA 120
HLTVKDEKNH HELDHRERES SANNSVSPSE SLRASEKHRG SADYSMEAKK RKAEEKDSLS 180
RYDSDGDKSD DLVVDVSNED PATPRVSPAH SPPENGLDKA RSLKKDAPTS PASVASSSST 240
PSSKTKDLGH NDKSSTPGLK SNTPTPRNDA PTPGTSTTPG LRSMPASALR TPISITSSYA 300
APFAMMSHHE MNGSLTSPGA YAGLHNIPPQ MSAAAAAAAA AYGRSPMVGF DPHPPMRATG 360
LPSSLASIPG GKPAYSFHVS ADGQMQPVPF PHDALAGPGI PRHARQINTL SHGEVVCAVT 420
ISNPTRHVYT GGKGCVKIWD ISQPGSKSPI SQLDCLNRDN YIRSCKLLPD GRTLIVGGEA 480
STLTIWDLAS PTPRIKAELT SSAPACYALA ISPDAKVCFS CCSDGNIAVW DLHNQTLVRQ 540
FQGHTDGASC IDISHDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF SLGYCPTGEW 600
LAVGMESSNV EVLHHTKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL LNAWRTPYGA 660
SIFQSKESSS VLSCDISADD KYIVTGSGDK KATVYEVIY 699 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR005617; Groucho/TLE_N.
 IPR009146; Groucho_enhance.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03920; TLE_N
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR01850; GROUCHOFAMLY.