CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004216
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 2, facilitated glucose transporter member 2 
Protein Synonyms/Alias
 Glucose transporter type 2, liver; GLUT-2 
Gene Name
 Slc2a2 
Gene Synonyms/Alias
 Glut-2; Glut2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
270RGTEDVTKDINEMKKubiquitination[1]
276TKDINEMKKEKEEASubiquitination[1]
279INEMKKEKEEASTEQacetylation[2]
489KVPETKGKSFEEIAAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. 
Sequence Annotation
 MOD_RES 520 520 Phosphoserine.
 CARBOHYD 62 62 N-linked (GlcNAc...) (Probable).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MSEDKITGTL AFTVFTAVLS SFQFGYDIGV INAPQEVIIS HYRHVLGVPL DDRKAAINYD 60
VNGTDTPLTV TPAYTTPAPW DEEETEGSAH IVTMLWSLSV SSFAVGGMVA SFFGGWLGDK 120
LGRIKAMLAA NSLSLTGALL MGCSKFGPAH ALIIAGRSVS GLYCGLISGL VPMYIGEIAP 180
TTLRGALGTL HQLALVTGIL ISQIAGLSFI LGNQDHWHIL LGLSAVPALL QCLLLLFCPE 240
SPRYLYIKLE EEVRAKKSLK RLRGTEDVTK DINEMKKEKE EASTEQKVSV IQLFTDANYR 300
QPILVALMLH MAQQFSGING IFYYSTSIFQ TAGISQPVYA TIGVGAINMI FTAVSVLLVE 360
KAGRRTLFLT GMIGMFFCTI FMSVGLVLLD KFAWMSYVSM TAIFLFVSFF EIGPGPIPWF 420
MVAEFFSQGP RPTALALAAF SNWVCNFVIA LCFQYIADFL GPYVFFLFAG VVLVFTLFTF 480
FKVPETKGKS FEEIAAEFRK KSGSAPPRKA AVQMEFLASS ESV 523 
Gene Ontology
 GO:0005903; C:brush border; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0055056; F:D-glucose transmembrane transporter activity; IDA:UniProtKB.
 GO:0033300; F:dehydroascorbic acid transporter activity; IDA:UniProtKB.
 GO:0031018; P:endocrine pancreas development; TAS:Reactome. 
Interpro
 IPR002440; Glc_transpt_2.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 
PRINTS
 PR01191; GLUCTRSPORT2.
 PR00171; SUGRTRNSPORT.