CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thiamine transporter 1 
Protein Synonyms/Alias
 ThTr-1; ThTr1; Solute carrier family 19 member 2; Thiamine carrier 1; TC1 
Gene Name
 SLC19A2 
Gene Synonyms/Alias
 THT1; TRMA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
231CQRVNGIKVQNGGIVubiquitination[1]
256GWEDIESKIPLNMEEubiquitination[2]
484SVMKKCRKLEDPQSSubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 High-affinity transporter for the intake of thiamine. 
Sequence Annotation
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Deafness; Diabetes mellitus; Disease mutation; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 497 AA 
Protein Sequence
MDVPGPVSRR AAAAAATVLL RTARVRRECW FLPTALLCAY GFFASLRPSE PFLTPYLLGP 60
DKNLTEREVF NEIYPVWTYS YLVLLFPVFL ATDYLRYKPV VLLQGLSLIV TWFMLLYAQG 120
LLAIQFLEFF YGIATATEIA YYSYIYSVVD LGMYQKVTSY CRSATLVGFT VGSVLGQILV 180
SVAGWSLFSL NVISLTCVSV AFAVAWFLPM PQKSLFFHHI PSTCQRVNGI KVQNGGIVTD 240
TPASNHLPGW EDIESKIPLN MEEPPVEEPE PKPDRLLVLK VLWNDFLMCY SSRPLLCWSV 300
WWALSTCGYF QVVNYTQGLW EKVMPSRYAA IYNGGVEAVS TLLGAVAVFA VGYIKISWST 360
WGEMTLSLFS LLIAAAVYIM DTVGNIWVCY ASYVVFRIIY MLLITIATFQ IAANLSMERY 420
ALVFGVNTFI ALALQTLLTL IVVDASGLGL EITTQFLIYA SYFALIAVVF LASGAVSVMK 480
KCRKLEDPQS SSQVTTS 497 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005542; F:folic acid binding; IEA:InterPro.
 GO:0008517; F:folic acid transporter activity; NAS:UniProtKB.
 GO:0008518; F:reduced folate carrier activity; IEA:InterPro.
 GO:0015403; F:thiamine uptake transmembrane transporter activity; ISS:BHF-UCL.
 GO:0071934; P:thiamine transmembrane transport; IEA:Compara.
 GO:0015888; P:thiamine transport; NAS:UniProtKB.
 GO:0042723; P:thiamine-containing compound metabolic process; TAS:Reactome. 
Interpro
 IPR002666; Folate_carrier.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF01770; Folate_carrier 
SMART
  
PROSITE
  
PRINTS