UniProt Accession

 TUSA_ECOLI; P0A890; P37618; Q2M7D3 

Genbank Protein ID

 U00039; U00096; AP009048 

Genbank Nucleotide ID

 AAB18445.1; AAC76495.1; BAE77823.1 

Protein Name

 Sulfurtransferase TusA 

Protein Synonyms/Alias

 tRNA 2-thiouridine synthesizing protein A 

Gene Name

 tusA 

Gene Synonyms/Alias

 sirA; yhhP; b3470; JW3435 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
66	MEHELVAKETDGLPY	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD. Seems to affect the stability of sigma-S, particularly during the logarithmic growth phase. 

Sequence Annotation

 ACT_SITE 19 19 Cysteine persulfide intermediate.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Reference proteome; Transferase; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 81 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:EcoCyc.
 GO:0097163; F:sulfur carrier activity; IDA:EcoCyc.
 GO:0016783; F:sulfurtransferase activity; IEA:HAMAP.
 GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IMP:EcoCyc.
 GO:0002143; P:tRNA wobble position uridine thiolation; IMP:EcoCyc. 

Interpro

 IPR022931; Sulphurtransferase_TusA.
 IPR001455; TusA-like. 

Pfam

 PF01206; SirA 

SMART

  

PROSITE

 PS01148; UPF0033 

PRINTS