UniProt Accession

 Q5T795_HUMAN; Q5T795 

Genbank Protein ID

 AL096678; AL158813; AL353692 

Genbank Nucleotide ID

  

Protein Name

 Midasin 

Protein Synonyms/Alias

  

Gene Name

 MDN1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	LIAAKNEKSRSELGR	ubiquitination	[1]
33	ELGRFLAKQVWTPQD	ubiquitination	[1, 2, 3, 4, 5]
81	ERNAEAIKAGGQINH	ubiquitination	[1, 2, 4]
100	RLCVSMSKLIGNHPD	ubiquitination	[1, 3]
117	PFALRYFKDTSPVFQ	ubiquitination	[1, 2, 4, 5, 6]
208	HKLSFLKKIFNSDEL	ubiquitination	[1]
247	PEVSLWRKQKELQYL	ubiquitination	[1, 5]
249	VSLWRKQKELQYLQG	ubiquitination	[1, 2, 5]
350	AAVTGRTKPPQLLKV	ubiquitination	[1, 2]
356	TKPPQLLKVQLGDQT	ubiquitination	[1, 2]
366	LGDQTDSKMLLGMYR	ubiquitination	[1, 2, 3, 4]
519	SEHTSKLKMAEVIGS	ubiquitination	[1]
527	MAEVIGSKLNISRKK	ubiquitination	[1, 2, 3, 4]
563	GRVRLLRKQSEAVHL	ubiquitination	[1, 5]
610	VGETGTGKTSTIQYL	ubiquitination	[1, 3]
644	ADLLGGYKPVDHKLI	ubiquitination	[1, 2]
649	GYKPVDHKLIWLPLR	ubiquitination	[1]
669	LFAQTFSKKQNFTFL	ubiquitination	[1]
705	VHKSAVNKDGKDSET	ubiquitination	[1, 2]
708	SAVNKDGKDSETGLL	ubiquitination	[1]
717	SETGLLIKEKWEAFG	ubiquitination	[2]
719	TGLLIKEKWEAFGLR	ubiquitination	[1]
818	NPATDVGKRNLPPGI	ubiquitination	[1, 3, 5]
858	LKGLSVNKNTVQGII	ubiquitination	[1]
935	ASHPIVQKLICQHIV	ubiquitination	[1]
947	HIVPGNVKSLLKQPI	ubiquitination	[1, 3, 5]
951	GNVKSLLKQPIPEPK	ubiquitination	[1, 2, 4]
958	KQPIPEPKGGRLIQV	ubiquitination	[1]
1111	TETQEVVKAHPRFML	ubiquitination	[1, 2, 3, 4]
1161	ELETILHKRCSLPPS	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1181 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR027417; P-loop_NTPase. 

Pfam

 PF07728; AAA_5 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS