CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036405
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Hibch 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
54VITLNRPKFLNALSLacetylation[1, 2, 3]
54VITLNRPKFLNALSLsuccinylation[2]
86DTFLIIIKGAGGKAFacetylation[3]
91IIKGAGGKAFCAGGDacetylation[1, 2, 3, 4, 5]
91IIKGAGGKAFCAGGDsuccinylation[2]
100FCAGGDIKALSEAKKacetylation[1, 2, 3]
100FCAGGDIKALSEAKKsuccinylation[2]
100FCAGGDIKALSEAKKsuccinylation[2]
220THFVDSEKLRVLEEEacetylation[1, 2, 3]
220THFVDSEKLRVLEEEsuccinylation[2]
249VLESYHAKSKMDQDKacetylation[2, 3]
249VLESYHAKSKMDQDKsuccinylation[2]
256KSKMDQDKSIIFEEHacetylation[2, 3]
256KSKMDQDKSIIFEEHsuccinylation[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 311 AA 
Protein Sequence
MGQPYAWRLL SRVSSFRRAS VILQHLRMSM HTEAAEVLLE RRGCGGVITL NRPKFLNALS 60
LNMIRQIYPQ LKTWEQDPDT FLIIIKGAGG KAFCAGGDIK ALSEAKKARQ NLTQDLFREE 120
YILNNAIASC QKPYVALIDG ITMGGGVGLS VHGQFRVATE RSLFAMPETG IGLFPDVGGG 180
YFLPRLQGKL GYFLALTGYR LKGRDVHRAG IATHFVDSEK LRVLEEELLA LKSPSAEDVA 240
GVLESYHAKS KMDQDKSIIF EEHMDKINSC FSANTVEQII ENLRQDGSPF AIEQMKFSLT 300
KTRLQNGNQP I 311 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003824; F:catalytic activity; IEA:InterPro. 
Interpro
 IPR001753; Crotonase_core_superfam. 
Pfam
 PF00378; ECH 
SMART
  
PROSITE
  
PRINTS