CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013192
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 568 
Protein Synonyms/Alias
  
Gene Name
 ZNF568 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
130EVDEQIKKQQETLVRacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 48 119 KRAB.
 ZN_FING 222 244 C2H2-type 1.
 ZN_FING 250 272 C2H2-type 2.
 ZN_FING 278 300 C2H2-type 3.
 ZN_FING 306 328 C2H2-type 4.
 ZN_FING 334 356 C2H2-type 5.
 ZN_FING 362 384 C2H2-type 6.
 ZN_FING 390 412 C2H2-type 7.
 ZN_FING 418 440 C2H2-type 8.
 ZN_FING 446 468 C2H2-type 9.
 ZN_FING 474 496 C2H2-type 10.
 ZN_FING 502 524 C2H2-type 11.
 ZN_FING 530 552 C2H2-type 12.
 ZN_FING 558 580 C2H2-type 13.
 ZN_FING 586 608 C2H2-type 14.
 ZN_FING 614 636 C2H2-type 15.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 644 AA 
Protein Sequence
MTSQSSVISN SCVTMERLSH MMERKAWCSQ ESALSEEEED TTRPLETVTF KDVAVDLTQE 60
EWEQMKPAQR NLYRDVMLEN YSNLVTVGCQ VTKPDVIFKL EQEEEPWVME EEMFGRHCPE 120
VWEVDEQIKK QQETLVRKVT SISKKILIKE KVIECKKVAK IFPLSSDIVT SRQSFYDCDS 180
LDKGLEHNLD LLRYEKGCVR EKQSNEFGKP FYHCASYVVT PFKCNQCGQD FSHKFDLIRH 240
ERIHAGEKPY ECKECGKAFS RKENLITHQK IHTGEKPYKC NECGKAFIQM SNLIRHHRIH 300
TGEKPYACKD CWKAFSQKSN LIEHERIHTG EKPYECKECG KSFSQKQNLI EHEKIHTGEK 360
PYACNECGRA FSRMSSVTLH MRSHTGEKPY KCNKCGKAFS QCSVFIIHMR SHTGEKPYVC 420
SECGKAFSQS SSLTVHMRNH TAEKPYECKE CGKAFSRKEN LITHQKIHTG EKPYECSECG 480
KAFIQMSNLI RHQRIHTGEK PYACTVCGKA FSQKSNLTEH EKIHTGEKPY HCNQCGKAFS 540
QRQNLLEHEK IHTGEKPFKC NECGKAFSRI SSLTLHVRSH TGEKPYECNK CGKAFSQCSL 600
LIIHMRSHTG EKPFECNECG KAFSQRASLS IHKRGHTGER HQVY 644 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS