| Tag | Content |
|---|
| CPLM ID | CPLM-015140 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lethal(2) giant larvae protein homolog 2 |
Protein Synonyms/Alias | HGL |
Gene Name | LLGL2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | HLWSLKVKGGASELQ | ubiquitination | [1] | | 666 | RSRVSSRKRHPAGPP | ubiquitination | [1] | | 724 | YFADTYLKDSSRHCP | ubiquitination | [1] | | 926 | ERFSLSTKWLVEPRC | ubiquitination | [1] | | 970 | TQSDGEEKQPGLVME | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. |
Sequence Annotation | REPEAT 36 69 WD 1.
REPEAT 76 117 WD 2.
REPEAT 132 169 WD 3.
REPEAT 193 227 WD 4.
REPEAT 233 268 WD 5.
REPEAT 282 324 WD 6.
REPEAT 332 366 WD 7.
REPEAT 388 464 WD 8.
REPEAT 508 583 WD 9.
REPEAT 592 653 WD 10.
REPEAT 713 769 WD 11.
REPEAT 778 830 WD 12.
REPEAT 835 888 WD 13.
REPEAT 902 925 WD 14.
MOD_RES 653 653 Phosphoserine.
MOD_RES 1015 1015 Phosphoserine. |
Keyword | Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Exocytosis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1020 AA |
Protein Sequence | MRRFLRPGHD PVRERLKRDL FQFNKTVEHG FPHQPSALGY SPSLRILAIG TRSGAIKLYG 60
APGVEFMGLH QENNAVTQIH LLPGQCQLVT LLDDNSLHLW SLKVKGGASE LQEDESFTLR 120
GPPGAAPSAT QITVVLPHSS CELLYLGTES GNVFVVQLPA FRALEDRTIS SDAVLQRLPE 180
EARHRRVFEM VEALQEHPRD PNQILIGYSR GLVVIWDLQG SRVLYHFLSS QQLENIWWQR 240
DGRLLVSCHS DGSYCQWPVS SEAQQPEPLR SLVPYGPFPC KAITRILWLT TRQGLPFTIF 300
QGGMPRASYG DRHCISVIHD GQQTAFDFTS RVIGFTVLTE ADPAATFDDP YALVVLAEEE 360
LVVIDLQTAG WPPVQLPYLA SLHCSAITCS HHVSNIPLKL WERIIAAGSR QNAHFSTMEW 420
PIDGGTSLTP APPQRDLLLT GHEDGTVRFW DASGVCLRLL YKLSTVRVFL TDTDPNENFS 480
AQGEDEWPPL RKVGSFDPYS DDPRLGIQKI FLCKYSGYLA VAGTAGQVLV LELNDEAAEQ 540
AVEQVEADLL QDQEGYRWKG HERLAARSGP VRFEPGFQPF VLVQCQPPAV VTSLALHSEW 600
RLVAFGTSHG FGLFDHQQRR QVFVKCTLHP SDQLALEGPL SRVKSLKKSL RQSFRRMRRS 660
RVSSRKRHPA GPPGEAQEGS AKAERPGLQN MELAPVQRKI EARSAEDSFT GFVRTLYFAD 720
TYLKDSSRHC PSLWAGTNGG TIYAFSLRVP PAERRMDEPV RAEQAKEIQL MHRAPVVGIL 780
VLDGHSVPLP EPLEVAHDLS KSPDMQGSHQ LLVVSEEQFK VFTLPKVSAK LKLKLTALEG 840
SRVRRVSVAH FGSRRAEDYG EHHLAVLTNL GDIQVVSLPL LKPQVRYSCI RREDVSGIAS 900
CVFTKYGQGF YLISPSEFER FSLSTKWLVE PRCLVDSAET KNHRPGNGAG PKKAPSRARN 960
SGTQSDGEEK QPGLVMERAL LSDERAATGV HIEPPWGAAS AMAEQSEWLS VQAAR 1015 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0006887; P:exocytosis; IEA:UniProtKB-KW. GO:0032878; P:regulation of establishment or maintenance of cell polarity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |