UniProt Accession

 CU002_HUMAN; O43822; A8MPS9; O14993; Q8N5X6; Q99837; Q99838 

Genbank Protein ID

 Y11392; Z93322; U84569; U84570; AP001062; AP001754; CH471079; CH471079; BC031300; BC072012 

Genbank Nucleotide ID

 CAA72202.1; CAB07532.1; AAB46590.1; AAB46591.1; BAA95562.1; EAX09432.1; EAX09434.1; AAH31300.1; AAH72012.1 

Protein Name

 Protein C21orf2 

Protein Synonyms/Alias

 C21orf-HUMF09G8.5; YF5/A2 

Gene Name

 C21orf2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	SELHSVRKLNCWGSR	ubiquitination	[1]
84	LAELFYLKGLPRLRV	ubiquitination	[1]
120	RTLPRLQKLDNQAVT	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. 

Sequence Annotation

 REPEAT 19 40 LRR 1.
 REPEAT 41 62 LRR 2.
 REPEAT 63 84 LRR 3.
 DOMAIN 97 137 LRRCT.
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 177 177 Phosphoserine.  

Keyword

 Alternative splicing; Cilium biogenesis/degradation; Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 256 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0060271; P:cilium morphogenesis; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0008360; P:regulation of cell shape; IMP:UniProtKB. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 

Pfam

 PF12799; LRR_4 

SMART

 SM00446; LRRcap 

PROSITE

 PS51450; LRR 

PRINTS