UniProt Accession

 PVRL1_HUMAN; Q15223; O75465; Q2M3D3; Q9HBE6; Q9HBW2 

Genbank Protein ID

 X76400; AF060231; AY029539; BC104948; BC113471; AF252867; AF196768; AF196769; AF196770; AF196771; AF196774; AF196768; AF196769; AF196770; AF196771; AF196772; AF196773 

Genbank Nucleotide ID

 CAA53980.2; AAC23798.1; AAK33124.1; AAI04949.1; AAI13472.1; AAG16648.1; AAG16648.1; AAG16648.1; AAG16648.1; AAG16648.1; AAG16649.1; AAG16649.1; AAG16649.1; AAG16649.1; AAG16649.1; AAG16649.1; AAG16649.1 

Protein Name

 Poliovirus receptor-related protein 1 

Protein Synonyms/Alias

 Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Herpesvirus Ig-like receptor; HIgR; Nectin-1; CD111 

Gene Name

 PVRL1 

Gene Synonyms/Alias

 HVEC; PRR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
190	VSWETRLKGEAEYQE	ubiquitination	[1]
465	PKYDEDAKRPYFTVD	ubiquitination	[1, 2]
512	NDGSFISKKEWYV**	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. 

Sequence Annotation

 DOMAIN 31 141 Ig-like V-type.
 DOMAIN 149 238 Ig-like C2-type 1.
 DOMAIN 247 334 Ig-like C2-type 2.
 MOD_RES 422 422 Phosphoserine.
 MOD_RES 434 434 Phosphoserine.
 MOD_RES 435 435 Phosphoserine (By similarity).
 CARBOHYD 36 36 N-linked (GlcNAc...) (Potential).
 CARBOHYD 72 72 N-linked (GlcNAc...).
 CARBOHYD 139 139 N-linked (GlcNAc...).
 CARBOHYD 202 202 N-linked (GlcNAc...).
 CARBOHYD 286 286 N-linked (GlcNAc...) (Potential).
 CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
 CARBOHYD 307 307 N-linked (GlcNAc...) (Potential).
 CARBOHYD 332 332 N-linked (GlcNAc...).
 DISULFID 51 124
 DISULFID 172 226
 DISULFID 269 316  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Ectodermal dysplasia; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 517 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015026; F:coreceptor activity; TAS:ProtInc.
 GO:0042803; F:protein homodimerization activity; ISS:HGNC.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0002934; P:desmosome organization; IEA:Compara.
 GO:0070166; P:enamel mineralization; IEA:Compara.
 GO:0007157; P:heterophilic cell-cell adhesion; ISS:HGNC.
 GO:0007156; P:homophilic cell adhesion; ISS:HGNC.
 GO:0006955; P:immune response; NAS:UniProtKB.
 GO:0006826; P:iron ion transport; IEA:Compara.
 GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Compara.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0046718; P:viral entry into host cell; NAS:UniProtKB. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr. 

Pfam

 PF08205; C2-set_2
 PF07686; V-set 

SMART

 SM00409; IG
 SM00406; IGv 

PROSITE

 PS50835; IG_LIKE 

PRINTS