[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
Functional Description
Sequence Annotation
NP_BIND 84 89 ATP 1 (Potential). NP_BIND 425 426 ATP 1. NP_BIND 532 537 ATP 2. NP_BIND 747 748 ATP 2. NP_BIND 784 788 ATP 2. NP_BIND 863 867 ATP 2. REGION 1 12 Hydrophobic. REGION 13 475 Regulatory. REGION 84 88 Glucose-6-phosphate 1 binding. REGION 172 173 Substrate 1 binding. REGION 208 209 Substrate 1 binding. REGION 291 294 Substrate 1 binding. REGION 413 415 Glucose-6-phosphate 1 binding. REGION 476 917 Catalytic. REGION 532 536 Glucose-6-phosphate 2 binding. REGION 603 604 Substrate 2 binding. REGION 620 621 Substrate 2 binding. REGION 656 657 Substrate 2 binding. REGION 682 683 Substrate 2 binding. REGION 861 863 Glucose-6-phosphate 2 binding. BINDING 30 30 ATP 1. BINDING 155 155 Substrate 1. BINDING 209 209 Glucose-6-phosphate 1. BINDING 232 232 Glucose-6-phosphate 1. BINDING 235 235 Substrate 1. BINDING 260 260 Substrate 1. BINDING 345 345 ATP 1. BINDING 449 449 Glucose-6-phosphate 1. BINDING 657 657 Glucose-6-phosphate 2. BINDING 680 680 ATP 2. BINDING 680 680 Glucose-6-phosphate 2. BINDING 708 708 Substrate 2. BINDING 742 742 Substrate 2. BINDING 897 897 Glucose-6-phosphate 2. MOD_RES 1 1 N-acetylmethionine. MOD_RES 27 27 Phosphotyrosine (By similarity).
Keyword
3D-structure; Acetylation; Allosteric enzyme; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Disease mutation; Glycolysis; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transferase.