UniProt Accession

 GLRX2_YEAST; P17695; D6VTD4; Q6B234 

Genbank Protein ID

 S45268; U33057; AY692896; BK006938 

Genbank Nucleotide ID

 AAB23389.1; AAB64953.1; AAT92915.1; DAA12344.1 

Protein Name

 Glutaredoxin-2, mitochondrial 

Protein Synonyms/Alias

 Glutathione-dependent oxidoreductase 2; Thioltransferase 

Gene Name

 GRX2 

Gene Synonyms/Alias

 TTR; TTR1; YDR513W; D9719.17 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
51	VKDLIGQKEVFVAAK	ubiquitination	[1]
129	NSDLETLKKNGKLAE	acetylation	[2]
133	ETLKKNGKLAEILKP	ubiquitination	[1]
139	GKLAEILKPVFQ***	acetylation	[2]
139	GKLAEILKPVFQ***	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. 

Sequence Annotation

 DOMAIN 41 143 Glutaredoxin.
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 91 91 Phosphoserine.
 DISULFID 61 64 Redox-active.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Electron transport; Mitochondrion; Phosphoprotein; Redox-active center; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0015036; F:disulfide oxidoreductase activity; IMP:SGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0004602; F:glutathione peroxidase activity; IDA:SGD.
 GO:0004364; F:glutathione transferase activity; IDA:SGD.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR011767; GLR_AS.
 IPR002109; Glutaredoxin.
 IPR011899; Glutaredoxin_euk/vir.
 IPR014025; Glutaredoxin_subgr.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS51354; GLUTAREDOXIN_2 

PRINTS

 PR00160; GLUTAREDOXIN.