| Tag | Content |
|---|
| CPLM ID | CPLM-018180 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | G-protein-signaling modulator 2 |
Protein Synonyms/Alias | Pins homolog |
Gene Name | Gpsm2 |
Gene Synonyms/Alias | Lgn; Pins |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 155 | LGNVYHAKGKSFGCP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. |
Sequence Annotation | REPEAT 24 57 TPR 1.
REPEAT 62 95 TPR 2.
REPEAT 102 135 TPR 3.
REPEAT 142 184 TPR 4.
REPEAT 202 235 TPR 5.
REPEAT 242 275 TPR 6.
REPEAT 282 315 TPR 7.
REPEAT 322 355 TPR 8.
DOMAIN 490 512 GoLoco 1.
DOMAIN 543 565 GoLoco 2.
DOMAIN 594 616 GoLoco 3.
DOMAIN 628 650 GoLoco 4.
MOD_RES 408 408 Phosphoserine.
MOD_RES 484 484 Phosphoserine (By similarity).
MOD_RES 487 487 Phosphothreonine (By similarity).
MOD_RES 540 540 Phosphoserine (By similarity).
MOD_RES 564 564 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 679 AA |
Protein Sequence | MEGNLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT 60
LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE 120
AIVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG CPGPQDTGEF PEDVRNALQA 180
AVDLYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA 240
ERRAYSNLGN AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK 300
AIDYHLKHLA IAQELKDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDKSG 360
ELTARLNLSD LQMVLGLSYS TNNSMMSENI EIDGSLHGAG AKLGRRHSME NLELMKLTPE 420
KVPNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKSGSA CTKVLQDASN SVDHRAPRSQ 480
KKISSDTIGD EGFFDLLRRF QSNRMDDQRC HLQGNCRTTS TAAASATPKL MKAPSVSVVS 540
PNTDEFLDLL ASSQSRRLDD QRASFSNLPG LRLTKGNSPS VLERLMTNDK KEPDEDFFDI 600
LVKCQGSRLD DQRCAPPSAA TKGPTVPDED FFSLILRSQA KRMDEQRVLL QRDPNRDSEF 660
GLKELLQNNA LLEFKHSGK 679 |
Gene Ontology | GO:0045177; C:apical part of cell; IDA:MGI. GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro. GO:0000132; P:establishment of mitotic spindle orientation; IMP:MGI. GO:0060487; P:lung epithelial cell differentiation; IMP:MGI. GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |