UniProt Accession

 OXDA_RAT; O35078 

Genbank Protein ID

 AB003400; BC088395 

Genbank Nucleotide ID

 BAA22840.1; AAH88395.1 

Protein Name

 D-amino-acid oxidase 

Protein Synonyms/Alias

 DAAO; DAMOX; DAO 

Gene Name

 Dao 

Gene Synonyms/Alias

 Dao1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
32	PAQPLHMKIYADRFT	acetylation	[1]
107	EVPDPFWKSTVLGFR	acetylation	[1]
157	RLTERGVKFIHRKVA	acetylation	[1]
336	FGKILEEKNLSRMPP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. 

Sequence Annotation

 NP_BIND 3 17 FAD (By similarity).
 NP_BIND 36 37 FAD (By similarity).
 NP_BIND 43 44 FAD (By similarity).
 NP_BIND 48 50 FAD (By similarity).
 NP_BIND 311 315 FAD (By similarity).
 MOTIF 344 346 Microbody targeting signal.
 BINDING 52 52 Substrate (By similarity).
 BINDING 163 163 FAD; via amide nitrogen and carbonyl
 BINDING 181 181 FAD (By similarity).
 BINDING 216 216 Substrate (By similarity).
 BINDING 227 227 Substrate (By similarity).
 BINDING 282 282 Substrate (By similarity).
 BINDING 312 312 Substrate; via carbonyl oxygen (By
 BINDING 316 316 FAD (By similarity).  

Keyword

 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0003884; F:D-amino-acid oxidase activity; IEA:EC.
 GO:0071949; F:FAD binding; IEA:Compara.
 GO:0055130; P:D-alanine catabolic process; IEA:Compara.
 GO:0036088; P:D-serine catabolic process; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; IEA:Compara.
 GO:0006551; P:leucine metabolic process; IEA:Compara.
 GO:0006562; P:proline catabolic process; IEA:Compara. 

Interpro

 IPR023209; D-aa_oxidase.
 IPR006181; D-amino_acid_oxidase_CS.
 IPR006076; FAD-dep_OxRdtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01266; DAO 

SMART

  

PROSITE

 PS00677; DAO 

PRINTS