CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014139
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RING finger protein 219 
Protein Synonyms/Alias
  
Gene Name
 RNF219 
Gene Synonyms/Alias
 C13orf7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
189KEANKKLKLENGGLVubiquitination[1]
225AVAALQSKVEQYEREubiquitination[1, 2]
245KALERSDKYIEELESubiquitination[1, 2]
264LKNSSEEKEAMNSICubiquitination[1]
283SADGKGSKGSEEDVVubiquitination[1]
292SEEDVVSKNQGDSARubiquitination[1, 2, 3]
333ARQESTSKADLNCSKubiquitination[1]
371LEREWGNKPSDCVPYubiquitination[1]
379PSDCVPYKDEELYDLubiquitination[1]
417VVQAGGSKKHSNHLRubiquitination[4]
418VQAGGSKKHSNHLRKubiquitination[1]
425KHSNHLRKLVFDDFCubiquitination[1, 2]
455SRSENEKKSECFSSPubiquitination[1, 2]
502ISSKLSEKSGLCLSKacetylation[2]
502ISSKLSEKSGLCLSKubiquitination[1, 2]
509KSGLCLSKRLNSIRSubiquitination[1]
560SPCNNGFKSLDLDGLubiquitination[1, 2]
569LDLDGLSKSSQGSEFubiquitination[1, 3]
582EFLEEPDKLEEKTELubiquitination[1, 2]
586EPDKLEEKTELNLSKubiquitination[1]
698STSFVPEKRNKNVNQubiquitination[1]
710VNQSTKRKIQSSLSSubiquitination[1, 2]
722LSSASPSKATKS***ubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
 ZN_FING 18 56 RING-type; degenerate.
 MOD_RES 719 719 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 726 AA 
Protein Sequence
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS QCPACRVPIT 60
PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE DEIDCLQKEV EELKSKNLSL 120
ESQIKTILDP LTLVQGNQNE DKHLVTDNPS KINPETVAEW KKKLRTANEI YEKVKDDVDK 180
LKEANKKLKL ENGGLVRENL RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL 240
ERSDKYIEEL ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK 300
QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE VMLDVTDTSM 360
DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL STPENRESSV VQAGGSKKHS 420
NHLRKLVFDD FCDSSNVSNK DSSEDDISRS ENEKKSECFS SPKTGFWDCC STSYAQNLDF 480
ESSEGNTIAN SVGEISSKLS EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE 540
LDSMMSESDN SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ 600
LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF SQGILLSSSH 660
RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN KNVNQSTKRK IQSSLSSASP 720
SKATKS 726 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS