UniProt Accession

 T3HPD_HUMAN; Q96EM0; Q96LJ5 

Genbank Protein ID

 AK058165; AL159140; BC012131 

Genbank Nucleotide ID

 BAB71696.1; AAH12131.1 

Protein Name

 Trans-L-3-hydroxyproline dehydratase 

Protein Synonyms/Alias

 Trans-3-hydroxy-l-proline dehydratase 

Gene Name

 L3HYPDH 

Gene Synonyms/Alias

 C14orf149 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	SGPTLLAKRRYMRQH	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. 

Sequence Annotation

 REGION 105 106 Substrate binding (By similarity).
 REGION 274 275 Substrate binding (By similarity).
 ACT_SITE 104 104 Proton acceptor (By similarity).
 BINDING 269 269 Substrate (By similarity).  

Keyword

 Complete proteome; Lyase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0016836; F:hydro-lyase activity; IDA:UniProtKB.
 GO:0050346; F:trans-L-3-hydroxyproline dehydratase activity; IEA:EC. 

Interpro

 IPR008794; Pro_racemase. 

Pfam

 PF05544; Pro_racemase 

SMART

  

PROSITE

  

PRINTS