CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GMP reductase 
Protein Synonyms/Alias
  
Gene Name
 GMPR2 
Gene Synonyms/Alias
 hCG_40198 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31NDVKLDFKDVLLRPKubiquitination[1]
295SSEMAMKKYAGGVAEubiquitination[1]
377KTVEVPFKGDVEHTIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MTSCLPALRF IATPRLSAMP HIDNDVKLDF KDVLLRPKRS TLKSRSEVDL TRSFSFRNSK 60
QTYSGVPIIA ANMDTVGTFE MAKVLCKFSL FTAVHKHYSL VQWQEFAGQN PDCLEHLAAS 120
SGTGSSDFEQ LEQILEAIPQ VKYICLDVAN GYSEHFVEFV KDVRKRFPQH TIMAGNVVTG 180
EMVEELILSG ADIIKVGIGP GSVCTTRKKT GVGYPQLSAV MECADAAHGL KGHIISDGGC 240
SCPGDVAKAF GAGADFVMLG GMLAGHSESG GELIERDGKK YKLFYGMSSE MAMKKYAGGV 300
AEYRYVWRPR SLVIVWRQNS WLLRGGWYSS QRSMVNRGSM LGSVEKSLGL RNPEGEDNKV 360
FPTLRASEGK TVEVPFKGDV EHTIRDILGG IRSTCTYVGA AKLKELSRRT TFIRVTQQVN 420
PIFSEAC 427 
Gene Ontology
 GO:0003920; F:GMP reductase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009117; P:nucleotide metabolic process; IEA:InterPro. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR005993; GMP_reduct1.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 
Pfam
 PF00478; IMPDH 
SMART
  
PROSITE
 PS00487; IMP_DH_GMP_RED 
PRINTS