UniProt Accession

 PUR7_YEAST; P27616; D6VPM4 

Genbank Protein ID

 M61209; M67445; L22015; X60549; BK006935 

Genbank Nucleotide ID

 AAA34396.1; AAA34398.1; AAC04963.1; CAA43043.1; DAA06994.1 

Protein Name

 Phosphoribosylaminoimidazole-succinocarboxamide synthase 

Protein Synonyms/Alias

 SAICAR synthetase 

Gene Name

 ADE1 

Gene Synonyms/Alias

 YAR015W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
83	LVDIAPGKTIFDYLP	acetylation	[1]
260	ESQDSYDKQFLRDWL	ubiquitination	[2]
291	IVDRTRAKYIEAYET	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Purine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 306 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IDA:SGD.
 GO:0006189; P:'de novo' IMP biosynthetic process; IDA:SGD. 

Interpro

 IPR013816; ATP_grasp_subdomain_2.
 IPR001636; SAICAR_synth.
 IPR018236; SAICAR_synthetase_CS. 

Pfam

 PF01259; SAICAR_synt 

SMART

  

PROSITE

 PS01057; SAICAR_SYNTHETASE_1
 PS01058; SAICAR_SYNTHETASE_2 

PRINTS