CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026313
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Semaphorin-4A 
Protein Synonyms/Alias
 cDNA FLJ75147 
Gene Name
 SEMA4A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
497APNLNSWKQDMERGNubiquitination[1]
624GIPREHVKVPLTRVSubiquitination[1]
689ETLRPGEKAPLSREQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 723 AA 
Protein Sequence
MPRVRYYAGD ERRALSFFHQ KGLQDFDTLL LSGDGNTLYV GAREAILALD IQDPGVPRLK 60
NMIPWPASDR KKSECAFKKK SNETQCFNFI RVLVSYNVTH LYTCGTFAFS PACTFIELQD 120
SYLLPISEDK VMEGKGQSPF DPAHKHTAVL VDGMLYSGTM NNFLGSEPIL MRTLGSQPVL 180
KTDNFLRWLH HDASFVAAIP STQVVYFFFE ETASEFDFFE RLHTSRVARV CKNDVGGEKL 240
LQKKWTTFLK AQLLCTQPGQ LPFNVIRHAV LLPADSPTAP HIYAVFTSQW QVGGTRSSAV 300
CAFSLLDIER VFKGKYKELN KETSRWTTYR GPETNPRPGS CSVGPSSDKA LTFMKDHFLM 360
DEQVVGTPLL VKSGVEYTRL AVETAQGLDG HSHLVMYLGT TTGSLHKAVV SGDSSAHLVE 420
EIQLFPDPEP VRNLQLAPTQ GAVFVGFSGG VWRVPRANCS VYESCVDCVL ARDPHCAWDP 480
ESRTCCLLSA PNLNSWKQDM ERGNPEWACA SGPMSRSLRP QSRPQIIKEV LAVPNSILEL 540
PCPHLSALAS YYWSHGPAAV PEASSTVYNG SLLLIVQDGV GGLYQCWATE NGFSYPVISY 600
WVDSQDQTLA LDPELAGIPR EHVKVPLTRV SGGAALAAQQ SYWPHFVTVT VLFALVLSGA 660
LIILVASPLR ALRARGKVQG CETLRPGEKA PLSREQHLQS PKECRTSASD VDADNNCLGT 720
EVA 723 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0016525; P:negative regulation of angiogenesis; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0010594; P:regulation of endothelial cell migration; IEA:Compara.
 GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Compara.
 GO:0045063; P:T-helper 1 cell differentiation; IEA:Compara. 
Interpro
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002165; Plexin_repeat.
 IPR027231; Semaphorin.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF01437; PSI
 PF01403; Sema 
SMART
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS51004; SEMA 
PRINTS