UniProt Accession

 MFF_HUMAN; Q9GZY8; Q567U1; Q658R6; Q9BVZ1; Q9H690; Q9NRG8 

Genbank Protein ID

 AK026137; AF246239; AF226049; AF258660; AC097662; BC000797; BC093024; AL833032 

Genbank Nucleotide ID

 BAB15373.1; AAG44486.1; AAF86949.1; AAG44658.1; AAY24252.1; AAH00797.1; AAH93024.1; CAH56328.1 

Protein Name

 Mitochondrial fission factor 

Protein Synonyms/Alias

  

Gene Name

 MFF 

Gene Synonyms/Alias

 C2orf33; AD030; AD033; GL004 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	MRVPEKLKVAPPNAD	ubiquitination	[1, 2]
109	LIQSTPFKPLALKTP	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a role in mitochondrial and peroxisomal fission. 

Sequence Annotation

 MOD_RES 115 115 Phosphothreonine.
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 172 172 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphothreonine.
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 229 229 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0032592; C:integral to mitochondrial membrane; IDA:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
 GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
 GO:0016559; P:peroxisome fission; IMP:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
 GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB. 

Interpro

 IPR008518; FATE/Miff/Tango-11. 

Pfam

 PF05644; Miff 

SMART

  

PROSITE

  

PRINTS