CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014844
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 26A 
Protein Synonyms/Alias
 Vesicle protein sorting 26A 
Gene Name
 Vps26a 
Gene Synonyms/Alias
 Vps26 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
35EMKTEDGKVEKHYLFacetylation[1]
242IMDGAPVKGESIPIRubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity). 
Sequence Annotation
 MOD_RES 315 315 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MSFLGGFFGP ICEIDVALSD GETRKMAEMK TEDGKVEKHY LFYDGESVSG KVNLAFKQPG 60
KRLEHQGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE LTQSRSYDFE FMQVEKPYES 120
YIGANVRLRY FLKVTIVRRL TDLVKEYDLI VHQLATYPEV NNSIKMEVGI EDCLHIEFEY 180
NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEITGIG PSTTTETETI AKYEIMDGAP 240
VKGESIPIRL FLAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE 300
KLRKQRTNFH QRFESPESQA SAEQPEM 327 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030904; C:retromer complex; IEA:InterPro.
 GO:0031982; C:vesicle; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Compara.
 GO:0007034; P:vacuolar transport; IEA:InterPro. 
Interpro
 IPR005377; VPS26. 
Pfam
 PF03643; Vps26 
SMART
  
PROSITE
  
PRINTS