CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030837
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab GTPase-binding effector protein 2 
Protein Synonyms/Alias
 cDNA FLJ57369, highly similar to Rab GTPase-binding effector protein 2 
Gene Name
 RABEP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34EAQITALKQERQQQQubiquitination[1, 2, 3, 4]
55ERELGRLKQLLSRAYubiquitination[3]
90EIVLPMEKEIEELKAubiquitination[4]
426RVQQEQSKAQLPDLLubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 498 AA 
Protein Sequence
MAAAAPVAAD DDERRRRPGA DSISSYEAQI TALKQERQQQ QQDCEEKERE LGRLKQLLSR 60
AYPLDSLEKQ MEKAHEDSEK LREIVLPMEK EIEELKAKLL RAEELIQEIQ RRPRHAPSLH 120
GSTELLPLSR DPSPPLEPLE ELSGDGGPAA EAFAHNCDDS ASISSFSLGG GVGSSSSLPQ 180
SRQGLSPEQE ETASLVSTGT LVPEGIYLPP PGYQLVPDTQ WEQLQTEGRQ LQKDLESVSR 240
ERDELQEGLR RSNEDCAKQM QVLLAQVQNS EQLLRTLQGT VSQAQERVQL QMAELVTTHK 300
CLHHEVKRLN EENQGLRAEQ LPSSAPQGSQ QEQGEEESLP SSVPELQQLL CCTRQEARAR 360
LQAQEHGAER LRIEIVTLRE ALEEETVARA SLEGQLRVQR EETEVLEASL CSLRTEMERV 420
QQEQSKAQLP DLLSEQRAKV LRLQAELETS EQVQRDFVRL SQALQVRLER IRQAETLEQV 480
RSIMDEAPLT DVRDIKDT 498 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. 
Interpro
 IPR018514; Rabaptin_coiled-coil.
 IPR015390; Rabaptin_Rab5-bd_dom. 
Pfam
 PF09311; Rab5-bind
 PF03528; Rabaptin 
SMART
  
PROSITE
  
PRINTS