| Tag | Content |
|---|
| CPLM ID | CPLM-013125 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin repeat domain-containing protein 27 |
Protein Synonyms/Alias | VPS9 domain-containing protein; VPS9-ankyrin-repeat protein |
Gene Name | Ankrd27 |
Gene Synonyms/Alias | Varp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 764 | DLVPLLLKHGAYSGA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be a Rab21 guanine exchange factor and regulate endosome dynamics. |
Sequence Annotation | DOMAIN 233 371 VPS9.
REPEAT 396 426 ANK 1.
REPEAT 462 491 ANK 2.
REPEAT 495 524 ANK 3.
REPEAT 528 557 ANK 4.
REPEAT 564 593 ANK 5.
REPEAT 597 627 ANK 6.
REPEAT 668 698 ANK 7.
REPEAT 742 771 ANK 8.
REPEAT 775 804 ANK 9.
REPEAT 808 837 ANK 10.
REPEAT 841 870 ANK 11.
MOD_RES 1022 1022 Phosphothreonine (By similarity). |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1048 AA |
Protein Sequence | MALYDEDLLK NPFYLALQKW RPDLCSKVAQ IHGIVLVPCR GSLPGSVQAS CQFESYVLVP 60
TEGHFQTLDG KAVVIEGNRI KLGAGFACLL SVPILFEETF YNEKEESFSI LCIAHPLERR 120
ETSEEPSAPA DPFSLKTIED VREFLGRHSE KFDKNIASFH RTFRECERKS LRHHIDSVNA 180
LYTKCLQQLL RDSHLKVLAK QEAQMNLMKQ AVEMYVHHDI YDLIFKYVGT MEASEDAAFN 240
KITRSLQDLQ QKDIGVKPEF SFNIPRAKRE LGQLNKCTSP QQKLLCLRKV VQLMTQSPSQ 300
RVNLETMCAD DLLSVLLYLL VKTEIPNWMA NLSYIKNFRF SSSAKDELGY CLTSVEAAIE 360
YIRQGSLSTK TPDAEGFGDR LFLKQRMNLL SQMTSTPIDC LFKHIASGNQ KEVERLLSQD 420
DQDKDAMQKM CHPLCSCEDC EKLISGRLND PSVVTPFSRD DRGQTPLHVA ALCGQASLID 480
FLVSKGAVVN ATDYHGSTPL HLACQKGFQS VTLLLLHYKA STEVQDNNGN TPLHLACTYG 540
QEDCVKALVY YDVQACRLDI GNEKGDTALH IAARWGYEGI IETLLQNGAP TAVQNRLKET 600
PLKCALNSKI LSIMEAHHLS SDRRPRPSEV PAQSPTRSVD SISQGSSTSS FSSISVSFRQ 660
EEVKKDYREV EKLLRAVADG DLEMVRYLLE WTEDDLDDVE DAISTVDLEF CHPLCQCPKC 720
APAQKLARIS ANGLSVNVTN QDGFSPLHMA ALHGRTDLVP LLLKHGAYSG ARNTSQAVPL 780
HLACQQGHFQ VAKCLLDSNA KPNKKDLSGN TPLICACSAG HHEVAALLLQ HGASINACNN 840
KGNTALHEAV MGRHTLVVEL LLFYGASVDI LNKRQYTAAD CAEQDSKIME LLQVVPGCVA 900
SLDSVEEADH EGYVTVEIRR KWNPKMYNLP EEPLRRQFCL INPGGRFQER TSRETMGRDR 960
SVPDLAGRSL QEPEKQRVTG KQSDLSDLSR YQTSEEGNKG LPERPVSRQA APGHRPMVRR 1020
HTVNDAAILQ VPEVTVHLTT HEASVPQS 1048 |
Gene Ontology | GO:0005769; C:early endosome; IEA:Compara. GO:0005764; C:lysosome; IEA:Compara. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Compara. GO:0045022; P:early endosome to late endosome transport; IEA:Compara. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |