Tag | Content |
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CPLM ID | CPLM-022748 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mortality factor 4-like protein 2 |
Protein Synonyms/Alias | MORF-related gene X protein; Sid 393; Transcription factor-like protein MRGX |
Gene Name | Morf4l2 |
Gene Synonyms/Alias | Kiaa0026; Sid393 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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277 | LFTASDYKVASADYH | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity). |
Sequence Annotation | DOMAIN 117 288 MRG. MOD_RES 71 71 Phosphoserine (By similarity). MOD_RES 262 262 Phosphotyrosine. MOD_RES 267 267 Phosphoserine. |
Keyword | Chromatin regulator; Complete proteome; DNA damage; DNA repair; Growth regulation; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 288 AA |
Protein Sequence | MSSRKQASQT RGQQSAEEDN FKKPTRSNMQ RSKMRGAASG KKSAGSQPKN LDPALPGRWG 60 GRSAENPPSG SVRKTRKNKQ KAPGNGDGGS TSEVPQPPRK KRARADPTVE SEEAFKSRME 120 VKVKIPEELK PWLVEDWDLV TRQKQLFQLP AKKNVDAILE EYANCKKSQG NVDNKEYAVN 180 EVVGGIKEYF NVMLGTQLLY KFERPQYAEI LLAHPDAPMS QIYGAPHLLR LFVRIGAMLA 240 YTPLDEKSLA LLLGYLHDFL KYLAKNSASL FTASDYKVAS ADYHRKAL 288 |
Gene Ontology | GO:0005730; C:nucleolus; IEA:Compara. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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