CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mediator of DNA damage checkpoint protein 1 
Protein Synonyms/Alias
  
Gene Name
 Mdc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
149RSLLTIEKTPRIRIEacetylation[1, 2]
770REIQTVEKAMGIPKEacetylation[1]
1497AEEVTQGKPTRSRRTacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1708 AA 
Protein Sequence
MESTQVIDWD AEEEEETELS SGSLGYSVEP IGQLRLFSGT HGPERDFPLY LGKNVVGRSP 60
DCSVALPFPS ISKQHAVIEI SAWNKAPILQ DCGSLNGTQI VKPPRVLPPG VSHRLRDQEL 120
ILFADFPCQY HRLDVPPPLV PRSLLTIEKT PRIRIESQNS RVLLAADSEE EGDFPSGRCV 180
ANGQRNTASP SATVVPESDE EVSSPAPSVP GPSSPFGLGS DTDEEQGQQP GVEESSLADS 240
SGAAGEAEQP EANGTTAGIQ AQPTEHKLKD TKVKKEAGRA GVSDGSVLER SPTLGEDSDT 300
EVDEDHKPGF ADSETDVEEE RIPVTPPVAP VKKNQVLLAV GIGDPEAPGV AHLQDCLAGS 360
GTDVEDKTAL DVPLERNHTP MVINSDTDEE EEEEEEEVSA ALTLAHLKER GIGLWSRDPG 420
AEEVKSQPQV LVEQSQSASG RDSDTDVEEE SSGRKREIIP DSPMDVDEAL TVTQPESQPP 480
RRPNDADEYM DMSSPGSHLV VNQASFAVVG KTRAQVEEEV PGPSVILGEK HQVPLEGAQP 540
PEEAWETAVQ EGSSSPEAAA SVRPSQQPVA EDAGTECATA VSEQESTLEV RSQSGSPAAP 600
VEQVVIHTDT SGDPTLPQRE GAQTPTGRER EAHVGRTKSA KECCDAEPED LCLPATQCFV 660
EGESQHPEAV QSLENEPTQL FPCTLPQEPG PSHLSLQTPG ADTLDVPWEV LATQPFCLRE 720
QSETSELHEA HGSQPSLPRE PPGHQHLVHT SPVHTELLRI EGREIQTVEK AMGIPKEMAD 780
RMTPEREPLE REIRGRTENS ERDVIGEELI QGTKDREPKK VLARDSQRKE ADKDLEGNRE 840
SLEVEIEMSK DSQKRERKVE KPEPKREWEP ADLEVTPDRG VTEEGSHDQK GQIASLTLKP 900
GVGVKDLEGL ASAPIITGSQ ADGGKGDPLS PGRQQRGRLS CQTTPAGKAS RGDPEPPDHC 960
LFSSVPEAST QSLLTSQSQK QSTPQPLFST SSSEIPLPES LHTKPNVRPR RSSRMTPSPH 1020
SSAALKPNTT CPTNQPAASR PTSRPTRGRA NRSSTRTPEL IVPVDPELQP STSTEQPVIP 1080
KLTSQVTEGR VQMPEPLLTG PEIQSPTSTE QSVTPDRKPR ATRGRPSKSP NKTPEPLIST 1140
GPELQPPTSI EQPVIPKPTS RVTRGRPRKS SVRTPESVVS TGPELQPLTS IEQPVIPEPR 1200
ATRGRPSKSS IKTPESVVPT GPELQPLTSA KQPVTPNLTS RASRGRSSKS IRTPEPVVQT 1260
GPEFHPSTST EQPDTREPSS QARTRRSAVK TPEASVPTTP ELQPFTSKKQ PAPKPTALVT 1320
QGRTYKPSTE DCESVGPVAP DFEPSTSTDH LVTPKVTDQS LTLQSSPLSA SPVSSTPDLK 1380
PPVPIAQPVT PEPIPQANHQ RKRRAAGKQG SRTVPLGHKS YSALSEPEPQ SSASQSSGAS 1440
EADSPRQKRP RRQASQKTVV IKEEPVETEV KEEPQETAIP TPEKRKRDHA EEVTQGKPTR 1500
SRRTKPNQET APKVLFTGVM DSRGERAVLA LGGSLASSVN EASHLVTDRI RRTVKFLCAL 1560
GKGIPILSLN WLYQSRKAGC FLPPDDYLVT DPEQEKNFSF SLRDSLCRAR ERRLLEDYEI 1620
HVTPGVQPPP PQMGEIISCC GGTFLPSMPH SYKLHRVIIT CTEDLPRCAI PSRLGLPLLS 1680
PEFLLTGVLK QEATPEAFVL SNLEMSST 1708 
Gene Ontology
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0005634; C:nucleus; ISO:MGI. 
Interpro
 IPR001357; BRCT_dom.
 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA 
SMART
 SM00292; BRCT
 SM00240; FHA 
PROSITE
 PS50172; BRCT
 PS50006; FHA_DOMAIN 
PRINTS