UniProt Accession

 GLNK_ECOLI; P0AC55; P38504; P77118; Q2MBX6 

Genbank Protein ID

 U40429; S79842; U82664; U00096; AP009048 

Genbank Nucleotide ID

 AAD14836.1; AAA87955.1; AAB40206.1; AAC73553.1; BAE76230.1 

Protein Name

 Nitrogen regulatory protein P-II 2 

Protein Synonyms/Alias

  

Gene Name

 glnK 

Gene Synonyms/Alias

 ybaI; b0450; JW0440 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
9	KLVTVIIKPFKLEDV	acetylation	[1]
12	TVIIKPFKLEDVREA	acetylation	[1]
34	GLTVTEVKGFGRQKG	acetylation	[1]
58	YSVNFLPKVKIDVAI	acetylation	[1]
79	EVIDIVSKAAYTGKI	acetylation	[1]
85	SKAAYTGKIGDGKIF	acetylation	[1]
90	TGKIGDGKIFVAELQ	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity). 

Sequence Annotation

 MOD_RES 51 51 O-UMP-tyrosine (By similarity).  

Keyword

 3D-structure; Complete proteome; Nucleotide-binding; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 112 AA 

Protein Sequence

Gene Ontology

 GO:0030234; F:enzyme regulator activity; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0045848; P:positive regulation of nitrogen utilization; IMP:EcoCyc.
 GO:0050790; P:regulation of catalytic activity; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002187; N-reg_PII.
 IPR011322; N-reg_PII-like_a/b.
 IPR015867; N-reg_PII/ATP_PRibTrfase_C.
 IPR017918; N-reg_PII_CS.
 IPR002332; N-reg_PII_urydylation_site. 

Pfam

 PF00543; P-II 

SMART

 SM00938; P-II 

PROSITE

 PS00638; PII_GLNB_CTER
 PS51343; PII_GLNB_DOM
 PS00496; PII_GLNB_UMP 

PRINTS

 PR00340; PIIGLNB.