UniProt Accession

 IKBP1_HUMAN; Q5VVH5 

Genbank Protein ID

 AL450327; CH471051; BC112253; BC112255 

Genbank Nucleotide ID

 CAH70883.1; EAW48721.1; AAI12254.1; AAI12256.1 

Protein Name

 Interleukin-1 receptor-associated kinase 1-binding protein 1 

Protein Synonyms/Alias

  

Gene Name

 IRAK1BP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MSLQKTPPTRVF	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity). 

Sequence Annotation

 REGION 1 91 Intrinsically disordered.
 REGION 240 260 Required for nuclear localization (NLS)
 MOD_RES 56 56 Phosphoserine (By similarity).
 MOD_RES 62 62 Phosphoserine (By similarity).
 MOD_RES 235 235 Phosphoserine (By similarity).
 MOD_RES 237 237 Phosphothreonine (By similarity).
 MOD_RES 242 242 Phosphoserine (By similarity).
 MOD_RES 247 247 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007497; DUF541. 

Pfam

 PF04402; SIMPL 

SMART

  

PROSITE

  

PRINTS