CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032449
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SMARCA4 protein 
Protein Synonyms/Alias
  
Gene Name
 SMARCA4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
399LAGDLRTKATIELKAubiquitination[1]
405TKATIELKALRLLNFubiquitination[1, 2]
437LETALNAKAYKRSKRubiquitination[1]
471QERKRRQKHQEYLNSubiquitination[1]
690VIHVESGKILTGTDAubiquitination[1]
1145DLYRASGKFELLDRIubiquitination[1, 3]
1526FIQLPSRKELPEYYEubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1681 AA 
Protein Sequence
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPIPTQG 60
PGGYPQDNMH QMHKPMESMH EKGMSDDPRY NQMKGMGMRS GGHAGMGPPP SPMDQHSQGY 120
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGADPQ ALGQQNRGPT PFNQNQLHQL 180
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP 240
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ 300
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PMVPLHQKQS RITPIQKPRG 360
LDPVEILQER EYRLQARIAH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV 420
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL 480
QHAKDFKEYH RSVTGKIQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK 540
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KENERIEKER MRRLMAEDEE 600
GYRKLIDQKK DKRLAYLLQQ TDEYVANLTE LVRQHKAAQV AKEKKKKKKK KKAENAEGQT 660
PAIGPDGEPL DETSQMSDLP VKVIHVESGK ILTGTDAPKA GQLEAWLEMN PGYEVAPRSD 720
SEESGSEEEE EEEEEEQPQA AQPPTLPVEE KKKIPDPDSD DVSEVDARHI IENAKQDVDD 780
EYGVSQALAR GLQSYYAVAH AVTERVDKQS ALMVNGVLKQ YQIKGLEWLV SLYNNNLNGI 840
LADEMGLGKT IQTIALITYL MEHKRINGPF LIIVPLSTLS NWAYEFDKWA PSVVKVSYKG 900
SPAARRAFVP QLRSGKFNVL LTTYEYIIKD KHILAKIRWK YMIVDEGHRM KNHHCKLTQV 960
LNTHYVAPRR LLLTGTPLQN KLPELWALLN FLLPTIFKSC STFEQWFNAP FAMTGEKVDL 1020
NEEETILIIR RLHKVLRPFL LRRLKKEVEA QLPEKVEYVI KCDMSALQRV LYRHMQAKGV 1080
LLTDGSEKDK KGKGGTKTLM NTIMQLRKIC NHPYMFQHIE ESFSEHLGFT GGIVQGLDLY 1140
RASGKFELLD RILPKLRATN HKVLLFCQMT SLMTIMEDYF AYRGFKYLRL DGTTKAEDRG 1200
MLLKTFNEPG SEYFIFLLST RAGGLGLNLQ SADTVIIFDS DWNPHQDLQA QDRAHRIGQQ 1260
NEVRVLRLCT VNSVEEKILA AAKYKLNVDQ KVIQAGMFDQ KSSSHERRAF LQAILEHEEQ 1320
DEEEDEVPDD ETVNQMIARH EEEFDLFMRM DLDRRREEAR NPKRKPRLME EDELPSWIIK 1380
DDAEVERLTC EEEEEKMFGR GSRHRKEVDY SDSLTEKQWL KTLKAIEEGT LEEIEEEVRQ 1440
KKSSRKRKRD SDAGSSTPTT STRSRDKDDE SKKQKKRGRP PAEKLSPNPP NLTKKMKKIV 1500
DAVIKYKDSS SGRQLSEVFI QLPSRKELPE YYELIRKPVD FKKIKERIRN HKYRSLNDLE 1560
KDVMLLCQNA QTFNLEGSLI YEDSIVLQSV FTSVRQKIEK EDDSEGEESE EEEEGEEEGS 1620
ESESRSVKVK IKLGRKEKAQ DRLKGGRRRP SRGSRAKPVV SDDDSEEEQE EDRSGSGSEE 1680
D 1681 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR006576; BRK_domain.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR014978; Gln-Leu-Gln_QLQ.
 IPR013999; HAS_subgr.
 IPR014012; Helicase/SANT-assoc_DNA-bd.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR006562; HSA.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF07533; BRK
 PF00439; Bromodomain
 PF00271; Helicase_C
 PF07529; HSA
 PF08880; QLQ
 PF00176; SNF2_N 
SMART
 SM00592; BRK
 SM00297; BROMO
 SM00487; DEXDc
 SM00490; HELICc
 SM00573; HSA
 SM00951; QLQ 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51204; HSA 
PRINTS
 PR00503; BROMODOMAIN.