CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022733
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 
Protein Synonyms/Alias
 Lysyl hydroxylase 3; LH3 
Gene Name
 Plod3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
708CRISSPRKGWALLHPacetylation[1]
708CRISSPRKGWALLHPsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. 
Sequence Annotation
 DOMAIN 650 741 Fe2OG dioxygenase.
 ACT_SITE 732 732 Potential.
 METAL 670 670 Iron (By similarity).
 METAL 672 672 Iron (By similarity).
 METAL 722 722 Iron (By similarity).
 CARBOHYD 66 66 N-linked (GlcNAc...).
 CARBOHYD 286 286 N-linked (GlcNAc...) (Potential).
 CARBOHYD 551 551 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Dioxygenase; Endoplasmic reticulum; Glycoprotein; Iron; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Signal; Vitamin C. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 741 AA 
Protein Sequence
MAAAGPEPRL LLLLLLLLPP LPPVTSASDR PRGANAVNPD KLLVITVATA ETEGYRRFLQ 60
SAEFFNYTVR TLGLGQEWRG GDVARTVGGG QKVRWLKKEM EKYADQKDMI IMFVDSYDVI 120
LASSPTELLK KFVQSGSHLL FSAESFCWPE WGLAEQYPEV GMGKRFLNSG GFIGFAPTIH 180
QIVRQWNYKD DDDDQLFYTQ LYLDPGLREK LKLSLDHKSR IFQNLNGALD EVILKFDQNR 240
VRIRNVAYDT LPVVVHGNGP TKLQLNYLGN YVPNGWTPQG GCGFCNQTLR TLPGGQPPPR 300
VLLAVFVEQP TPFLPRFLQR LLLLDYPPDR ISLFLHNSEV YHEPHIADAW PQLQDHFSAV 360
KLVGPEEALS AGEARDMAMD SCRQNPECEF YFSLDADAVL TNPETLRVLI EQNRKVIAPM 420
LSRHGKLWSN FWGALSPNEY YARSEDYVEL VQRKRVGVWN VPYISQAYVI RGETLRTELP 480
QKEVFSSSDT DPDMAFCKSV RDKGIFLHLS NQHEFGRLLA TSRYDTDHLH PDLWQIFDNP 540
VDWREQYIHE NYSRALDGEG LVEQPCPDVY WFPLLTEQMC DELVEEMEHY GQWSGGRHED 600
SRLAGGYENV PTVDIHMKQV GYEDQWLQLL RTYVGPMTEY LFPGYHTKTR AVMNFVVRYR 660
PDEQPSLRPH HDSSTFTLNV ALNHKGVDYE GGGCRFLRYD CRISSPRKGW ALLHPGRLTH 720
YHEGLPTTRG TRYIMVSFVD P 741 
Gene Ontology
 GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0033823; F:procollagen glucosyltransferase activity; IDA:MGI.
 GO:0008475; F:procollagen-lysine 5-dioxygenase activity; IDA:MGI.
 GO:0070831; P:basement membrane assembly; IMP:MGI.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0001886; P:endothelial cell morphogenesis; IMP:MGI.
 GO:0048730; P:epidermis morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0060425; P:lung morphogenesis; IMP:MGI.
 GO:0021915; P:neural tube development; IMP:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0042311; P:vasodilation; IMP:MGI. 
Interpro
 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR006620; Pro_4_hyd_alph.
 IPR001006; Procol_lys_dOase. 
Pfam
 PF03171; 2OG-FeII_Oxy 
SMART
 SM00702; P4Hc 
PROSITE
 PS51471; FE2OG_OXY
 PS01325; LYS_HYDROXYLASE 
PRINTS