UniProt Accession

 LMNA_RAT; P48679 

Genbank Protein ID

 X66870; X76297 

Genbank Nucleotide ID

 CAA47342.1; CAA53945.1 

Protein Name

 Prelamin-A/C 

Protein Synonyms/Alias

 Lamin-A/C 

Gene Name

 Lmna 

Gene Synonyms/Alias

 Lmn1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
208	KEELDFQKNIYSEEL	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity). 

Sequence Annotation

 REGION 1 130 Interaction with MLIP (By similarity).
 REGION 1 33 Head.
 REGION 34 383 Rod.
 REGION 34 70 Coil 1A.
 REGION 71 80 Linker 1.
 REGION 81 218 Coil 1B.
 REGION 219 242 Linker 2.
 REGION 243 383 Coil 2.
 REGION 384 665 Tail.
 MOTIF 417 422 Nuclear localization signal (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 3 3 Phosphothreonine (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 18 18 Phosphoserine (By similarity).
 MOD_RES 19 19 Phosphothreonine (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 108 108 N6-acetyllysine (By similarity).
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 270 270 N6-acetyllysine (By similarity).
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 301 301 Phosphoserine (By similarity).
 MOD_RES 311 311 N6-acetyllysine (By similarity).
 MOD_RES 390 390 Phosphoserine.
 MOD_RES 392 392 Phosphoserine (By similarity).
 MOD_RES 395 395 Phosphoserine (By similarity).
 MOD_RES 398 398 Phosphoserine (By similarity).
 MOD_RES 404 404 Phosphoserine (By similarity).
 MOD_RES 406 406 Phosphoserine (By similarity).
 MOD_RES 407 407 Phosphoserine (By similarity).
 MOD_RES 409 409 Phosphoserine (By similarity).
 MOD_RES 414 414 Phosphoserine (By similarity).
 MOD_RES 431 431 Phosphoserine (By similarity).
 MOD_RES 450 450 N6-acetyllysine (By similarity).
 MOD_RES 458 458 Phosphoserine (By similarity).
 MOD_RES 463 463 Phosphoserine (By similarity).
 MOD_RES 496 496 Phosphothreonine.
 MOD_RES 500 500 Phosphoserine.
 MOD_RES 505 505 Phosphothreonine (By similarity).
 MOD_RES 510 510 Phosphothreonine.
 MOD_RES 573 573 Phosphoserine (By similarity).
 MOD_RES 575 575 Phosphoserine (By similarity).
 MOD_RES 629 629 Phosphoserine (By similarity).
 MOD_RES 633 633 Phosphoserine (By similarity).
 MOD_RES 637 637 Phosphoserine (By similarity).
 MOD_RES 653 653 Phosphoserine (By similarity).
 MOD_RES 662 662 Cysteine methyl ester (By similarity).
 LIPID 662 662 S-farnesyl cysteine (By similarity).
 CROSSLNK 201 201 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Isopeptide bond; Lipoprotein; Methylation; Nucleus; Phosphoprotein; Prenylation; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 665 AA 

Protein Sequence

Gene Ontology

 GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0016363; C:nuclear matrix; IDA:RGD.
 GO:0005198; F:structural molecule activity; TAS:RGD.
 GO:0006998; P:nuclear envelope organization; TAS:RGD.
 GO:0090343; P:positive regulation of cell aging; ISS:UniProtKB.
 GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; IEP:RGD. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR001322; Lamin_tail_dom. 

Pfam

 PF00038; Filament
 PF00932; LTD 

SMART

  

PROSITE

 PS00226; IF 

PRINTS