CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neural cell adhesion molecule 1 
Protein Synonyms/Alias
 N-CAM-1; NCAM-1; CD56 
Gene Name
 Ncam1 
Gene Synonyms/Alias
 Ncam 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
770AGPGAKGKDMEEGKAubiquitination[1]
776GKDMEEGKAAFSKDEubiquitination[1]
785AFSKDESKEPIVEVRubiquitination[1]
820TPLTEPEKGPVETKSubiquitination[1]
826EKGPVETKSEPQESEubiquitination[1]
835EPQESEAKPAPTEVKubiquitination[1]
852PNEATQTKENESKA*ubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 
Sequence Annotation
 DOMAIN 20 111 Ig-like C2-type 1.
 DOMAIN 116 205 Ig-like C2-type 2.
 DOMAIN 212 302 Ig-like C2-type 3.
 DOMAIN 309 414 Ig-like C2-type 4.
 DOMAIN 417 502 Ig-like C2-type 5.
 DOMAIN 507 606 Fibronectin type-III 1.
 DOMAIN 608 702 Fibronectin type-III 2.
 REGION 152 156 Heparin-binding (Potential).
 REGION 161 165 Heparin-binding (Potential).
 MOD_RES 784 784 Phosphoserine (By similarity).
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 CARBOHYD 316 316 N-linked (GlcNAc...) (Potential).
 CARBOHYD 348 348 N-linked (GlcNAc...) (Potential).
 CARBOHYD 434 434 N-linked (GlcNAc...) (Potential).
 CARBOHYD 460 460 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
 DISULFID 41 96 By similarity.
 DISULFID 139 189 By similarity.
 DISULFID 235 288 By similarity.
 DISULFID 330 396 By similarity.
 DISULFID 437 490 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Heparin-binding; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 858 AA 
Protein Sequence
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE 60
KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA EDGTQSEATV NVKIFQKLMF 120
KNAPTPQEFK EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK 180
KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF 240
PEPTMSWTKD GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 300
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS SEEKASWTRP 360
EKQETLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY LEVQYAPKLQ 420
GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN YSNIKIYNTP SASYLEVTPD 480
SENDFGNYNC TAVNRIGQES LEFILVQADT PSSPSIDRVE PYSSTAQVQF DEPEATGGVP 540
ILKYKAEWKS LGEEAWHSKW YDAKEANMEG IVTIMGLKPE TRYAVRLAAL NGKGLGEISA 600
ATEFKTQPVR EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI 660
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTAGLS 720
TGAIVGILIV IFVLLLVVMD ITCYFLNKCG LLMCIAVNLC GKAGPGAKGK DMEEGKAAFS 780
KDESKEPIVE VRTEEERTPN HDGGKHTEPN ETTPLTEPEK GPVETKSEPQ ESEAKPAPTE 840
VKTVPNEATQ TKENESKA 858 
Gene Ontology
 GO:0030426; C:growth cone; TAS:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005886; C:plasma membrane; TAS:RGD.
 GO:0008092; F:cytoskeletal protein binding; TAS:RGD.
 GO:0005104; F:fibroblast growth factor receptor binding; TAS:RGD.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0019902; F:phosphatase binding; IDA:RGD.
 GO:0007568; P:aging; IDA:RGD.
 GO:0016338; P:calcium-independent cell-cell adhesion; TAS:RGD.
 GO:0071241; P:cellular response to inorganic substance; IEP:RGD.
 GO:0007611; P:learning or memory; IDA:RGD.
 GO:0033555; P:multicellular organismal response to stress; IDA:RGD.
 GO:0060548; P:negative regulation of cell death; IMP:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0014012; P:peripheral nervous system axon regeneration; IEP:RGD.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IMP:RGD.
 GO:0051930; P:regulation of sensory perception of pain; IMP:RGD.
 GO:0042220; P:response to cocaine; IDA:RGD.
 GO:0014076; P:response to fluoxetine; IDA:RGD.
 GO:0010288; P:response to lead ion; IDA:RGD.
 GO:0021794; P:thalamus development; IDA:RGD. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR009138; Neural_cell_adh. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS
 PR01838; NCAMFAMILY.