CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025965
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-aminolevulinate synthase, erythroid-specific, mitochondrial 
Protein Synonyms/Alias
 Aminolevulinate, delta-, synthase 2 (Sideroblastic/hypochromic anemia), isoform CRA_a 
Gene Name
 ALAS2 
Gene Synonyms/Alias
 hCG_18952 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12EVALGWNKKKRLFCEubiquitination[1]
13VALGWNKKKRLFCEDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 574 AA 
Protein Sequence
MRGGEVALGW NKKKRLFCED FRFKMVTAAM LLQCCPVLAR GPTSLLGKVV KTHQFLFGIG 60
RCPILATQGP NCSQIHLKAT KAGGDSPSWA KGHCPFMLSE LQDGKSKIVQ KAAPEVQEDV 120
KAFKTGNYVF SYDQFFRDKI MEKKQDHTYR VFKTVNRWAD AYPFAQHFSE ASVASKDVSV 180
WCSNDYLGMS RHPQVLQATQ ETLQRHGAGA GGTRNISGTS KFHVELEQEL AELHQKDSAL 240
LFSSCFVAND STLFTLAKIL PGCEIYSDAG NHASMIQGIR NSGAAKFVFR HNDPDHLKKL 300
LEKSNPKIPK IVAFETVHSM DGAICPLEEL CDVSHQYGAL TFVDEVHAVG LYGSRGAGIG 360
ERDGIMHKID IISGTLGKAF GCVGGYIAST RDLVDMVRSY AAGFIFTTSL PPMVLSGALE 420
SVRLLKGEEG QALRRAHQRN VKHMRQLLMD RGLPVIPCPS HIIPIRVGNA ALNSKLCDLL 480
LSKHGIYVQA INYPTVPRGE ELLRLAPSPH HSPQMMEDFV EKLLLAWTAV GLPLQDVSVA 540
ACNFCRRPVH FELMSEWERS YFGNMGPQYV TTYA 574 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:InterPro.
 GO:0003870; F:5-aminolevulinate synthase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006778; P:porphyrin-containing compound metabolic process; IEA:InterPro.
 GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro. 
Interpro
 IPR010961; 4pyrrol_synth_NH2levulA_synth.
 IPR015118; 5aminolev_synth_preseq.
 IPR001917; Aminotrans_II_pyridoxalP_BS.
 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2
 PF09029; Preseq_ALAS 
SMART
  
PROSITE
 PS00599; AA_TRANSFER_CLASS_2 
PRINTS