CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004362
UniProt Accession
Genbank Protein ID
 J05030 
Genbank Nucleotide ID
Protein Name
 Short-chain specific acyl-CoA dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 SCAD; Butyryl-CoA dehydrogenase 
Gene Name
 Acads 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
51TCRDFAEKELVPIAAacetylation[1]
62PIAAQLDKEHLFPTSacetylation[1]
72LFPTSQVKKMGELGLacetylation[1]
208TDRSRQNKGISAFLVacetylation[1]
226TPGLTLGKKEDKLGIacetylation[1]
262GEPGMGFKIAMQTLDacetylation[1]
306AFGAPLTKLQNIQFKacetylation[1]
335TWRAAMLKDNKKPFTacetylation[1]
339AMLKDNKKPFTKESAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 NP_BIND 152 161 FAD.
 NP_BIND 185 187 FAD.
 NP_BIND 365 369 FAD.
 NP_BIND 394 396 FAD.
 REGION 269 272 Substrate binding.
 ACT_SITE 392 392 Proton acceptor.
 BINDING 161 161 Substrate; via carbonyl oxygen.
 BINDING 297 297 FAD.
 BINDING 308 308 FAD (By similarity).
 BINDING 393 393 Substrate; via amide nitrogen.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 412 AA 
Protein Sequence
MAAALLARAG GSLGRALRAR DWRRLHTVYQ SVELPETHQM LRQTCRDFAE KELVPIAAQL 60
DKEHLFPTSQ VKKMGELGLL AMDVPEELSG AGLDYLAYSI ALEEISRGCA STGVIMSVNN 120
SLYLGPILKF GSSQQKQQWI TPFTNGDKIG CFALSEPGNG SDAGAASTTA REEGDSWVLN 180
GTKAWITNSW EASATVVFAS TDRSRQNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN 240
LIFEDCRIPK ENLLGEPGMG FKIAMQTLDM GRIGIASQAL GIAQASLDCA VKYAENRHAF 300
GAPLTKLQNI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKESAMAKL AASEAATAIS 360
HQAIQILGGM GYVTEMPAER YYRDARITEI YEGTSEIQRL VIAGHLLRSY RS 412 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IDA:BHF-UCL.
 GO:0031966; C:mitochondrial membrane; IDA:BHF-UCL.
 GO:0003995; F:acyl-CoA dehydrogenase activity; IDA:RGD.
 GO:0004085; F:butyryl-CoA dehydrogenase activity; IDA:RGD.
 GO:0000062; F:fatty-acyl-CoA binding; IDA:RGD.
 GO:0050660; F:flavin adenine dinucleotide binding; IDA:RGD.
 GO:0046359; P:butyrate catabolic process; IDA:RGD.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IDA:RGD.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0042594; P:response to starvation; IEP:RGD. 
Interpro
 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 
SMART
  
PROSITE
 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 
PRINTS