UniProt Accession

 SYT12_HUMAN; Q8IV01 

Genbank Protein ID

 BC037406 

Genbank Nucleotide ID

 AAH37406.1 

Protein Name

 Synaptotagmin-12 

Protein Synonyms/Alias

 Synaptotagmin XII; SytXII 

Gene Name

 SYT12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	DYRYLQQKYGESCAE	ubiquitination	[1]
233	DPTALEEKSLRFSVF	ubiquitination	[1]
316	NLIWTNDKTTADPFV	acetylation	[2]
336	QDGRKMSKKKTAVKR	acetylation	[2]
337	DGRKMSKKKTAVKRD	acetylation	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). 

Sequence Annotation

 DOMAIN 168 272 C2 1.
 DOMAIN 285 388 C2 2.  

Keyword

 Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Polymorphism; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 421 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. 

Interpro

 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting. 

Pfam

 PF00168; C2 

SMART

 SM00239; C2 

PROSITE

 PS50004; C2 

PRINTS