CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020039
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch domain-containing protein 3 
Protein Synonyms/Alias
 Protein Peas; Testis intracellular mediator protein 
Gene Name
 KLHDC3 
Gene Synonyms/Alias
 PEAS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63WTKLPPVKSAIRGQAubiquitination[1]
114AFDVNTHKWFTPRVSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in meiotic recombination process. 
Sequence Annotation
 REPEAT 25 77 Kelch 1.
 REPEAT 88 138 Kelch 2.
 REPEAT 139 189 Kelch 3.
 REPEAT 191 249 Kelch 4.
 REPEAT 251 301 Kelch 5.  
Keyword
 Complete proteome; Cytoplasm; Kelch repeat; Meiosis; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 382 AA 
Protein Sequence
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP 60
PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG ACNVLYAFDV NTHKWFTPRV 120
SGTVPGARDG HSACVLGKIM YIFGGYEQQA DCFSNDIHKL DTSTMTWTLI CTKGSPARWR 180
DFHSATMLGS HMYVFGGRAD RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR 240
SHSAFGYNGE LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG 300
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN LDQSCLPHDI 360
RWELNAMTTN SNISRPIVSS HG 382 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000790; C:nuclear chromatin; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0007131; P:reciprocal meiotic recombination; NAS:UniProtKB. 
Interpro
 IPR015915; Kelch-typ_b-propeller.
 IPR011498; Kelch_2. 
Pfam
 PF07646; Kelch_2 
SMART
  
PROSITE
  
PRINTS