UniProt Accession

 GLTP_HUMAN; Q9NZD2; Q53Z13; Q96J68 

Genbank Protein ID

 AF209704; AY372530; AY372531; AY372532; AK313457; CH471054; BC009932 

Genbank Nucleotide ID

 AAF33210.1; AAR85984.1; AAR85985.1; AAR87373.1; BAG36244.1; EAW97880.1; AAH09932.1 

Protein Name

 Glycolipid transfer protein 

Protein Synonyms/Alias

 GLTP 

Gene Name

 GLTP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	SGNITKIKAVYDTNP	ubiquitination	[1]
66	VYDTNPAKFRTLQNI	ubiquitination	[2, 3]
158	ALYAAPYKSDFLKAL	ubiquitination	[1]
167	DFLKALSKGQNVTEE	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. 

Sequence Annotation

 REPEAT 45 55 1.
 REPEAT 56 66 2.
 REGION 45 66 2 X 12 AA approximate tandem repeats.
 REGION 48 55 Glycolipid binding.
 BINDING 140 140 Glycolipid.
 BINDING 207 207 Glycolipid.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Lipid transport; Reference proteome; Repeat; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IC:HGNC.
 GO:0051861; F:glycolipid binding; IDA:HGNC.
 GO:0017089; F:glycolipid transporter activity; IDA:HGNC.
 GO:0046836; P:glycolipid transport; IDA:HGNC. 

Interpro

 IPR014830; Glycolipid_transfer_prot_dom. 

Pfam

 PF08718; GLTP 

SMART

  

PROSITE

  

PRINTS