UniProt Accession

 NPTN_HUMAN; Q9Y639; B2RAL7; B7Z4D3; B7ZLL2; Q17R52; Q59EJ9; Q6NVX7; Q9Y640 

Genbank Protein ID

 AF109126; AF109127; AK297184; AK314248; AB209812; CH471082; BC105979; BC117462; BC143880; BC143881 

Genbank Nucleotide ID

 AAD43217.1; AAD43218.1; BAH12519.1; BAG36914.1; BAD93049.1; EAW77931.1; AAI05980.1; AAI17463.1; AAI43881.1; AAI43882.1 

Protein Name

 Neuroplastin 

Protein Synonyms/Alias

 Stromal cell-derived receptor 1; SDR-1 

Gene Name

 NPTN 

Gene Synonyms/Alias

 SDFR1; SDR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
235	ANATIEVKAAPDITG	ubiquitination	[1]
244	APDITGHKRSENKNE	ubiquitination	[2]
249	GHKRSENKNEGQDAT	ubiquitination	[2]
364	IVVYEKRKRPDEVPD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). 

Sequence Annotation

 DOMAIN 29 134 Ig-like 1.
 DOMAIN 148 235 Ig-like 2.
 DOMAIN 238 329 Ig-like 3.
 REGION 149 161 Narpin; mediates binding with FGFR1 and
 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).
 CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...).
 CARBOHYD 284 284 N-linked (GlcNAc...).
 CARBOHYD 296 296 N-linked (GlcNAc...).
 CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
 DISULFID 52 116 By similarity.
 DISULFID 170 218 By similarity.
 DISULFID 259 316 By similarity.  

Keyword

 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; ISS:HGNC.
 GO:0050839; F:cell adhesion molecule binding; ISS:HGNC.
 GO:0005105; F:type 1 fibroblast growth factor receptor binding; ISS:UniProtKB.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:UniProtKB.
 GO:0007156; P:homophilic cell adhesion; ISS:HGNC.
 GO:0060291; P:long-term synaptic potentiation; ISS:UniProtKB.
 GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; ISS:HGNC.
 GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
 GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR027112; Neuroplastin. 

Pfam

 PF07679; I-set 

SMART

 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS