UniProt Accession

 B7Z7P5_HUMAN; B7Z7P5 

Genbank Protein ID

 AC009961; AK302347 

Genbank Nucleotide ID

 BAH13681.1 

Protein Name

 E3 ubiquitin-protein ligase MARCH7 

Protein Synonyms/Alias

 cDNA FLJ52435, highly similar to Homo sapiens membrane-associated ring finger (C3HC4) 7 (MARCH7), mRNA 

Gene Name

 MARCH7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	DHDSKRPKLSCTNCT	ubiquitination	[1]
498	PERLQKIKESLLLED	ubiquitination	[1]
548	VHQDCMKKWLQAKIN	ubiquitination	[1]
553	MKKWLQAKINSGSSL	ubiquitination	[1]
570	VTTCELCKEKLELNL	ubiquitination	[1, 2, 3]
572	TCELCKEKLELNLED	ubiquitination	[1, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 666 AA 

Protein Sequence

Gene Ontology

 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR011016; Znf_RING-CH.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF12906; RINGv 

SMART

 SM00744; RINGv 

PROSITE

 PS51292; ZF_RING_CH 

PRINTS