CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022275
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PCNA-interacting partner 
Protein Synonyms/Alias
 PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP 
Gene Name
 PARPBP 
Gene Synonyms/Alias
 C12orf48; PARI 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100KIYDDFLKNSNMLDLubiquitination[1]
158IPTSPTSKYNRDNEKubiquitination[1]
236RTIELGGKGYAPPPSubiquitination[1]
354YCGRDTVKALLVLLDubiquitination[1]
370EAANAPTKNKAELLYubiquitination[1]
405TQVNNSIKPLRERICubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 579 AA 
Protein Sequence
MAVFNQKSVS DMIKEFRKNW RALCNSERTT LCGADSMLLA LQLSMAENNK QHSGEFTVSL 60
SDVLLTWKYL LHEKLNLPVE NMDVTDHYED VRKIYDDFLK NSNMLDLIDV YQKCRALTSN 120
CENYNTVSPS QLLDFLSGKQ YAVGDETDLS IPTSPTSKYN RDNEKVQLLA RKIIFSYLNL 180
LVNSKNDLAV AYILNIPDRG LGREAFTDLK HAAREKQMSI FLVATSFIRT IELGGKGYAP 240
PPSDPLRTHV KGLSNFINFI DKLDEILGEI PNPSIAGGQI LSVIKMQLIK GQNSRDPFCK 300
AIEEVAQDLD LRIKNIINSQ EGVVALSTTD ISPARPKSHA INHGTAYCGR DTVKALLVLL 360
DEEAANAPTK NKAELLYDEE NTIHHHGTSI LTLFRSPTQV NNSIKPLRER ICVSMQEKKI 420
KMKQTLIRSQ FACTYKDDYM ISKDNWNNVN LASKPLCVLY MENDLSEGVN PSVGRSTIGT 480
SFGNVHLDRS KNEKVSRKST SQTGNKSSKR KQVDLDGENI LCDNRNEPPQ HKNAKIPKKS 540
NDSQNRLYGK LAKVAKSNKC TAKDKLISGQ AKLTQFFRL 579 
Gene Ontology
 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IMP:UniProtKB. 
Interpro
 IPR027417; P-loop_NTPase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS